📰 NASDAQ: BRTX - Announces SBIR Phase I Grant

[View online]( [UNSUBSCRIBE]( ALERT: NASDAQ: BRTX BREAKING NEWS! BioRestorative Therapies Announces SBIR Phase I Grant to Explore the Therapeutic Effects of ThermoStem® Targeting Polycystic Ovary Syndrome as an Indication --Non-Dilutive Grant Funding to Support Development of Brown Adipose-Based Therapeutic Programs Directed at Polycystic Ovary Syndrome -- MELVILLE, N.Y., Dec. 06, 2022 (GLOBE NEWSWIRE) -- [BioRestorative Therapies, Inc.]( (“BioRestorative”, “BRTX” or the “Company”) (NASDAQ:[BRTX]( a clinical stage company focused on stem cell-based therapies, today announced that it has been awarded a Small Business Innovation Research (SBIR) Phase I grant from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health. This collaborative research will be conducted in partnership with [Dr. Sheng Wu]( Associate Professor, Center for Metabolic Disease Research at Temple University, School of Medicine, Dr. Wu has received numerous national and international awards such as the Women in Endocrinology Young Investigator Award, Eugenia Rosemberg Abstract Award, Early Investigator Award from the Endocrine Society; Virendra B. Mahesh Award of Excellence in Endocrinology, and Endocrinology and Metabolism Section New Investigator Award from American Physiology Society. The specific objective of this NIH grant is to enable the development and evaluation of the Company’s [ThermoStem]( program for the treatment of polycystic ovary syndrome (PCOS). Therapeutic brown adipocyte transplantation is an emerging and novel therapy for PCOS. BRTX has developed proprietary methods for the generation of metabolically active brown adipocytes. “This new indication will expand BioRestorative’s current discovery pipeline focused on the novel brown fat therapy at the intersection of innate, adaptive metabolic regulation and women’s health. Our industry expertise in brown fat complements world class research conducted by Dr. Wu’s laboratory and thus strengthen our commitment to discover innovative solutions for patients with unmet medical needs.” said [Lance Alstodt]( CEO of BioRestorative Therapies. [PCOS]( affects 6-18% of reproductive age females, representing the most common endocrine disease in women and a $4.36 billion healthcare cost annually in the US. PCOS causes gynecological, dermatologic and metabolic comorbidities, and also imposes long-term risks of diabetes mellitus type 2 (T2D), cardiovascular diseases (CVD) and psychiatric problems including severe depression. PCOS is commonly associated with metabolic disorders, with 50-70% of PCOS patients showing insulin resistance and 10% with T2D, implying a potential causative link between them. Current standard of care includes lifestyle changes and multiple lines of medications with aims to relieve symptoms. Medications usually have moderate success rates, and have limited effects and long-term risks of T2D, CVD and psychiatric problems “There is a tremendous gap in the understanding of the metabolic dysfunction of PCOS and the underlying mechanisms remain largely incomplete. In addition, the development of more efficient, even personalized therapeutic strategies for the metabolic management of PCOS patients persists as an unmet need. ThermoStem® may provide a therapeutic option,” said Francisco Silva, Vice President of Research and Development of BioRestorative Therapies. 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