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Named in honor of the founder of New England Biolabs, this lectureship showcases those who have pioneered basic research, with substantial impact on molecular biology, to address issues affecting the world at large. This year's recipient is Jo Handelsman from The University of Wisconsin-Madison.
--------------------------------------------------------------- Finding THORâs Hammer: Multiomics search for the driver of a microbial community Microbiomes drive the health of virtually every ecosystem on Earth, mitigating global problems as disparate as climate change and human depression. Their staggering diversity makes communities difficult to study, preventing scientists from elucidating the principles that could guide interventions to improve the health of people or the environment. To reduce the complexity and enable molecular dissection, we developed a model microbiome containing three bacterial species originally isolated from plant roots: Pseudomonas koreensis, Flavobacterium johnsoniae, and Bacillus cereus. Using a spectrum of methods, we characterized interactions among the members and identified community-specific genes and small molecules. In a surprising twist of simplicity in the midst of a highly complex system, we found that P. koreensis and its antibiotic, koreenceine, influence global patterns of gene expression and metabolite profiles. The broad influence of one small molecule suggests new strategies to study and manage microbiomes. Thursday, October 12th
11:00 AM EDT
1 hour, 30 minutes [Register Today!]( Jo Handelsman Director of the Wisconsin Institute for Discovery, University of Wisconsin-Madison
Jo Handelsman is the director of the Wisconsin Institute for Discovery (WID) and a Vilas Research Professor and Howard Hughes Medical Institute Professor in the Department of Plant Pathology at the University of WisconsinâMadison. She joined the faculty at UW-Madison in 1985 where she served for 25 years before moving to Yale University in 2010. From 2014 to 2017, she served as a science advisor to President Barack Obama in her role as Associate Director for Science in the White House Office of Science and Technology Policy. After leaving the White House, Handelsman returned to UW-Madison where she continues to work on national policy as well as direct WID and pursue her own research on the soil and human microbiomes. In 2021 Handelsman published A World Without Soil, a book that presents the soil erosion crisis and policy recommendations to avert it. Handelsman is a renowned microbiologist whose research seeks to understand how microorganisms cooperate with and antagonize each other. She is known for pioneering the field of functional metagenomics. Handelsman has been elected to the National Academy of Sciences, the American Academy of Arts and Sciences, and the National Academy of Inventors and received the Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring from President Obama in 2011.
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