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Please join us for our upcoming webinar entitled: Induro⢠Reverse Transcriptase: A Robust, Thermostable, Intron-Encoded RT for Full-Length cDNA Synthesis Reverse transcriptases (RTs) are a diverse group of enzymes with RNA-dependent DNA polymerase activity which synthesize a complementary strand of DNA (cDNA) from RNA template. In vivo, RTs are responsible for replicating the retroviral genomic RNAs, multiplying mobile genetic elements, and maintaining the integrity of telomeres. In vitro, RTs remain the essential enzymatic tool for RNA analysis. Most applications utilize retroviral RTs, mainly due to their wide availability and their incorporation into well-established protocols. However, Group II Intron-encoded RTs possess unique properties such as higher processivity and better inhibitor tolerance. These desired features can potentially improve current workflows as well as enable new technologies. Recently we characterized a novel intron-encoded thermostable RT: Induro⢠Reverse Transcriptase. Induro exhibits unmatched processivity, supporting full length cDNA synthesis using short incubation times, and is more tolerant of common inhibitors compared to other RTs. When evaluated in direct RNA/cDNA sequencing workflows using Oxford Nanopore Technologies®, Induro generates the longest direct RNA reads or direct cDNA reads, improving 5â sequencing coverage of long transcripts. Wednesday, September 21st, 1:00 PM EST [Register Here]( Yan Xu, Ph.D.
Development Scientist III
Applications and Development Department Yan Xu is a Development Scientist III in the Applications and Development Department at New England Biolabs, Inc. Yan received her Ph.D. from Cornell University, where she characterized molecular and cellular processes involved in flower petal senescence. She then joined New England Biolabs in 2000 as a post-doctoral associate. During that time she created Nt.AlwI, the first commercially available engineered nicking endonuclease. While working in the Research Department, Yan also co-invented the Helicase-Dependent Amplification (HDA) technology, wherein helicases enable isothermal amplification via a mechanism similar to PCR but without heating steps. Since joining the Product Development Department in 2004, Yan has contributed her expertise in DNA-dependent DNA polymerases, reverse transcriptases, and related technologies to a wide range of development projects, with a focus on enzyme engineering and applications related to DNA and RNA detection. Her work has included leading roles in the development of products for PCR, cDNA synthesis, and RT-qPCR, among others.
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