VCs Should De-Risk Longevity Investments

Plus: Try Our New Longevity AI ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ February 9th, 2024 | [Read Online]( A Free Longevity Coach for Everyone. Our readers have been offered exclusive Beta Access, check it out via the link below. Good Morning , As the global population ages, the implications for economies, healthcare systems, and individual financial planning become increasingly significant. Today we are guided by a critical analysis of how these dynamics are reshaping investment strategies, policy frameworks, and personal finance management in response to the challenges and opportunities presented by extended lifespans. We begin by examining the nuanced role of venture capital in mitigating risks associated with longevity biotech investments. The dialogue with Kelsey Moody, CEO of Ichor Life Sciences, offers a window into the sophisticated approaches being adopted to validate scientific breakthroughs before financial commitments are made, highlighting the intersection of scientific rigor and investment acumen. The discourse then shifts to the macroeconomic level with the World Economic Forum's Longevity Economy Principles, which outline a strategic framework for supporting an aging population. These principles advocate for systemic changes that encompass financial resilience, healthcare, and inclusivity, aiming to construct an ecosystem that fosters healthy and financially secure longer lives. Finally, we navigate the personal dimension of longevity economics through the lens of financial literacy. Saboor Bayat's insights into the importance of longevity literacy in retirement planning illuminate the critical need for individuals to understand and strategically plan for the financial realities of extended life expectancies. Together, these discussions paint a comprehensive picture of the current state and future direction of longevity economics and private finance, providing valuable insights into the multifaceted efforts required to adapt to an aging world. Let’s dive in … FRIDAY SPOTLIGHT Healthspan vs. Lifespan ‘VCs should run experiments to derisk longevity investments’ Venture capital plays a pivotal role in advancing longevity biotech, a sector at the confluence of science and finance, aiming to extend human healthspan and lifespan. Kelsey Moody, CEO of Ichor Life Sciences, sheds light on the nuanced challenges and strategies in longevity biotech investments. He critiques the prevailing venture capital model, highlighting a significant gap in due diligence processes. Moody advocates for a more hands-on approach, where venture capitalists not only fund but actively engage in validating the scientific foundations of their potential investments through experiments. This method, he argues, can significantly mitigate risks associated with the reproducibility crisis in life sciences. Moody's insights reveal a deeper issue within the venture capital landscape: the reliance on surface-level evaluations over rigorous scientific validation. By sharing his company's strategy of conducting preliminary experiments to replicate key findings, Moody presents a blueprint for reducing investment risks and uncovering valuable opportunities that might otherwise be overlooked due to the inherent challenges of biotech startups. Furthermore, Moody touches on the strategic decisions facing longevity biotech startups, such as selecting disease indications for their therapies. This decision-making process is complicated by the multifaceted nature of aging, where a single therapeutic might impact multiple age-related diseases, yet not sufficiently to outperform existing treatments. Moody's discussion extends to the operational aspects of drug development in the longevity space, emphasizing the transition from basic research to the development of viable therapeutics. The conversation with Moody not only highlights the critical role of venture capital in derisking longevity biotech investments but also underscores the sector's complexities. It showcases the importance of a deeper, scientifically informed engagement by investors to navigate the intricacies of aging research and its translation into impactful therapies. [Longevity Technology]( The most striking discovery was in the elderly, where taurine levels were a staggering 80% lower than in their younger counterparts. This nutrient's potential seems promising, especially when considering its ability to add an estimated seven to eight years to human life. These 6 ‘Longevity Economy’ Principles Epidemiological observations have long hinted at a curious phenomenon: populations residing at high altitudes often live longer and seem less susceptible to certain diseases. This study sought to replicate these findings in a controlled animal setting, shedding light on the potential benefits of high-altitude living. The World Economic Forum's "Longevity Economy Principles" report serves as a manifesto for constructing a financial and social infrastructure that supports an aging global population. It outlines six principles designed to ensure individuals can lead financially resilient and healthy lives well into old age. These principles advocate for systemic changes across financial resilience, education, healthcare, employment, social connectivity, and equality to accommodate the demographic shift towards an older population, expected to more than double to 2.1 billion by 2050. The report delves into the necessity of financial resilience, recognizing the financial instability that key life events can impose on the elderly. It proposes collaborative efforts between the public and private sectors to create safety nets and encourage savings for retirement. The emphasis on universal financial education is particularly notable, addressing the global deficit in financial literacy and its contribution to wealth and health disparities. Healthy aging is identified as a cornerstone of the longevity economy, urging a shift from treating illness to preventing it, thereby enhancing life quality in older age. The principles also highlight the need to evolve job markets and skill-building initiatives to accommodate a multigenerational workforce, suggesting a move beyond traditional retirement ages. Social connection and addressing longevity inequalities across gender, race, and class are critical to ensuring that the benefits of a longer life are accessible to all. The report underscores the importance of designing inclusive systems that promote social engagement and address the systemic barriers that perpetuate inequalities. This comprehensive approach to fostering a resilient longevity economy suggests a paradigm shift in how societies plan for aging populations. It calls for a holistic strategy that combines financial, health, and social policies to create an environment where aging is not just a challenge to be managed but an opportunity to be embraced. [World Economic Forum]( Unravelling the Longevity Puzzle Saboor Bayat's article on the necessity of longevity literacy in retirement planning addresses a critical aspect of financial planning in an era of extended lifespans. It underscores the importance of understanding the financial implications of living longer, pointing out the gaps in public knowledge regarding life expectancy and its impact on retirement savings. The article highlights the role of financial advisers in bridging these gaps, using tools and discussions to tailor financial plans that accommodate potential long-term care needs and the costs of healthcare in retirement. Bayat emphasizes the complexity of planning for health care expenses, including Medicare and supplemental insurance, which can significantly erode retirement savings if not carefully managed. The potential need for long-term care, which affects approximately 70% of individuals turning 65, further complicates financial planning, underscoring the need for insurance solutions that cover these costs. Additionally, the article explores the financial dynamics of supporting aging parents and managing expectations around inheritance, factors that can significantly impact one’s financial stability in retirement. Bayat advocates for open family communication to address these issues, suggesting that financial planners encourage clients to have these difficult conversations. "Unraveling the Longevity Puzzle" presents longevity literacy as a critical component of retirement planning, necessitating a comprehensive approach that includes financial education, strategic healthcare planning, and family dialogue. By highlighting these considerations, Bayat contributes to a broader understanding of the financial challenges and strategies essential for securing a financially stable and worry-free retirement in an age of increasing life expectancy. [BNN]( Sima, the last surviving rat from the study, stands as a testament to the treatment's potential. She has already surpassed the typical lifespan for her species, drawing parallels to a human living beyond 126 years. In today's exploration through Longr Reads, we've engaged with the complex and evolving landscape of longevity economics and private finance, uncovering insights that sit at the heart of preparing for an aging global population. Through an in-depth analysis of venture capital's strategic approach to de-risking longevity biotech investments, we've seen the importance of marrying scientific rigor with financial acumen. Kelsey Moody's call for a more evidence-based investment strategy underscores the necessity of bridging the gap between science and finance to foster innovation in longevity therapies. The World Economic Forum's Longevity Economy Principles provide a blueprint for creating a financial and social environment conducive to aging well. These principles highlight the multifaceted approach needed to ensure financial resilience, health, and inclusivity for the elderly, suggesting a collaborative effort across public and private sectors to reimagine our aging societies. Finally, Saboor Bayat's discussion on longevity literacy brings to light the individual's role in navigating the financial complexities of extended lifespans. It emphasizes the importance of financial education, healthcare planning, and family communication in crafting a secure retirement strategy. Collectively, these discussions present a holistic view of the challenges and opportunities within the longevity economy. They underscore the imperative for a synergistic approach that combines innovative financial strategies, inclusive economic policies, and personal financial literacy to support a demographic shift towards longer, healthier lives. As we continue to chart this unexplored territory, the insights gleaned today will undoubtedly contribute to shaping a future where longevity is not just a demographic challenge but an opportunity for societal growth and personal fulfillment. Until next time, The Longr Reads Team "The future of healthcare lies in working hand-in-hand with technology." Bill Maris, Entrepreneur and Venture Capitalist Longr Reads' of the Week - How Longevity Will Arrive for Everyone ([Longevity Technology]( - The Potential of Longevity Therapeutics ([Strategy&]( - The Future of Longevity with Tony Robbins ([a1 ,k6z - Youtube]( Longr is building access to longevity across: generative AI, therapeutics, wellness products, clinics, research, community, and marketplaces. Transforming visionary concepts into tangible solutions - we are facilitating widespread adoption of longevity-enhancing products and platforms. [Advertise with us](mailto:partnerships@longr.io) // [Book a call with Longr](mailto:ir@longr.io) 107 North Orange Street, Wilmington, Delaware 19801, United States You received this email from Longr Reads. If you would like to unsubscribe, [click here](.