Take a Bike Ride for your Longevity

Your daily digest on longevity, investment, science & lifestyle ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ November 17th, 2023 | [Read Online]( Good Morning , Welcome to our latest exploration of longevity, where we delve into the fascinating intersection of lifestyle choices and cutting-edge science that are redefining human lifespan. Here we step into the world of the Blue Zones, where simple, natural habits pave the way to extraordinary longevity. We'll explore how activities like finding purpose, conscious eating, and fostering community are not just philosophies but practical steps towards a healthier life. Then, we'll shift gears to Harvard's groundbreaking research, where aging is being challenged not as an inevitable decline but as a reversible condition, opening doors to potential centuries-long lifespans. Finally, we contrast the opulence of a multimillion-dollar anti-aging regimen with the humble, yet potent, benefits of cycling, offering insights into the diverse approaches to aging. Join us as we uncover these intriguing narratives, each providing a unique lens through which we can view and possibly reshape our own journey towards health and longevity. Happy Friday … EVERY WEDNESDAY Research Round-up 9 Powerful Lifestyle Habits of the World’s Healthiest People In "9 Powerful Lifestyle Habits of the World’s Healthiest People," Christine Winder delves into the Blue Zones, regions renowned for exceptional longevity. These areas exemplify nine key habits: preferring natural activity over gym workouts; finding a life purpose, known as 'Ikigai' in Okinawa; and managing stress through unique cultural practices. Conscious eating, including the '80% rule' and a plant-centric diet with minimal meat, is essential. Moderate wine consumption, spiritual engagement, prioritizing family, and maintaining a positive social circle are also pivotal. These practices, deeply embedded in the community's lifestyle, contribute to their remarkable health and longevity. The article suggests integrating these habits into our lives through small, consistent changes, highlighting their potential to significantly enhance health and lifespan. [Everygirl]( The most striking discovery was in the elderly, where taurine levels were a staggering 80% lower than in their younger counterparts. This nutrient's potential seems promising, especially when considering its ability to add an estimated seven to eight years to human life. Has the first person to live to be 150 been born? Harvard researchers, led by Genetics Professor David Sinclair, have made a groundbreaking discovery in aging research. They've successfully reversed aging in mice by altering the epigenome, which controls DNA activity. This method deviates from the traditional belief that DNA mutations cause aging, suggesting instead that aging results from epigenetic degradation. Importantly, they found a backup copy of epigenetic information in cells, likening aging to a reversible software issue. The team's drug, in trials with nonhuman primates, aims to reset the body's age and potentially eradicate age-related diseases like Alzheimer's. Over 13 years of research have culminated in this finding, with significant implications: humans might live up to 150 years, and aging could be treated as a reversible condition, offering a unified approach to various age-related diseases. [Harvard Gazette]( Epidemiological observations have long hinted at a curious phenomenon: populations residing at high altitudes often live longer and seem less susceptible to certain diseases. This study sought to replicate these findings in a controlled animal setting, shedding light on the potential benefits of high-altitude living. $2m-a-year Blueprint project vs the humble bicycle In "Anti-aging lifestyles compared: $2m-a-year Blueprint project vs the humble bicycle," the article contrasts tech entrepreneur Bryan Johnson's $2 million annual anti-aging regimen with the benefits of regular cycling, represented by veteran cyclist Justin McKie. Johnson's extensive 'Blueprint' protocol includes monitoring numerous biomarkers and a strict vegan diet, while McKie relies on his cycling routine. The article examines McKie's physiological markers, like his superior VO2 max score, against Johnson's regimen, drawing insights from biogerontology experts. These experts emphasize the importance of balanced physical activity and nutrition over extreme measures. The article suggests that regular, moderate exercise like cycling might offer a more practical and accessible approach to anti-aging compared to costly and intensive programs. [Cycling Weekly]( Sima, the last surviving rat from the study, stands as a testament to the treatment's potential. She has already surpassed the typical lifespan for her species, drawing parallels to a human living beyond 126 years. As we wrap up this week's insightful exploration into the diverse realms of longevity, several key takeaways stand out. We've ventured into the Blue Zones, where simplicity in lifestyle intertwines with profound longevity, and observed Harvard's pioneering research that challenges our understanding of aging as a potentially reversible phenomenon. Additionally, the contrasting approaches to anti-aging – from a multimillion-dollar regimen to the simplicity of cycling – highlight the spectrum of strategies being pursued in the quest for extended healthspan. These narratives collectively underscore a pivotal theme: the pursuit of longevity is as varied as it is dynamic, blending age-old wisdom with cutting-edge science. Whether through small, sustainable lifestyle changes or groundbreaking scientific breakthroughs, the journey toward extended health and vitality continues to evolve, offering us a glimpse into a future where living well and long might become an attainable reality for many. Here's to continued discovery and innovation in the quest for longevity. Shall we go for a bike ride? The Longr Reads Team. "Exercise is king. Nutrition is queen. Put them together and you've got a kingdom." Jack LaLanne, Fitness Guru Longr Reads' of the Week - The start-ups seeking a cure for old age ([Financial Times]( - Interview: The US tech millionaire trying to reverse his age ([BBC News]( - Inconvenient Truths About Human Longevity ([Oxford Academic]( Longr is building access to longevity across: generative AI, therapeutics, wellness products, clinics, research, community, and marketplaces. Transforming visionary concepts into tangible solutions - we are facilitating widespread adoption of longevity-enhancing products and platforms. [Advertise with us](mailto:partnerships@longr.io) // [Book a call with Longr](mailto:ir@longr.io) 107 North Orange Street, Wilmington, Delaware 19801, United States You received this email from Longr Reads. If you would like to unsubscribe, [click here](.