CSFs: Burgeoning Potential in Inflammatory Disorders and Cancer

CSFs: Burgeoning Potential in Inflammatory Disorders and Cancer [Live Science](   Thursday 9 September 2021 [View this email online](   SPONSORED CONTENT [CSFs: Burgeoning Potential in Inflammatory Disorders and Cancer]( Colony-stimulating factors (CSFs) are growth factors that induce the clonal growth of hematopoietic progenitors. All CSFs control myeloid cell numbers, but each has a level of specificity to its target cells and effects. There is a growing interest in targeting these CSFs in inflammatory and autoimmune disorders, as well as cancer. The CSF family includes: • Macrophage colony-stimulating factor ([M-CSF/CSF1]( Binds to the homodimeric CSF1 receptor ([CSF1R/CD115]( to regulate the survival, proliferation, differentiation, and function of myeloid lineage cells. Alterations in CSF1R/CD115 have been associated with cancer and Alzheimer’s disease. • Granulocyte-macrophage colony-stimulating factor ([GM-CSF/CSF2]( Binds to the GM-CSF receptor (GM-CSFR/CD116), which consists of a unique α-chain ([CSF2RA]( and the common β subunit ([CSF2RB/CD131]( to stimulate the maturation of stem cells and the differentiation of granulocytes and monocytes. • Granulocyte colony-stimulating factor ([G-CSF/CSF3]( Binds to the homodimeric G-CSF receptor ([G-CSFR/CD114]( to stimulate all cells in the granulocyte lineage. It has been associated with acute myeloid leukemia, bone marrow transplants, and neutropenia. • Multiple colony-stimulating factor or interleukin 3 ([IL-3]( Binds to the IL-3 receptor (IL-3R) that consists of a unique α-chain ([IL3RA]( paired with the common β subunit (CD131). The common beta subunit is shared with GM-CSF and [IL-5]( receptors. IL-3 stimulates the growth of immature progenitor cells of all myeloid lineages. It has been associated with autoimmune diseases. CSF Family Ligands and Receptors Sino Biological has developed high activity CSF ligand and receptor proteins from various species to help study the biology of CSFs and receptors. We have also developed different functional isoforms for them. • Activity Validated by Cell Proliferation Assay Human GM-CSF (Cat#: [10015-HNAH]( Human M-CSF (Cat#: [11792-HNAH]( Cell Proliferation Assay Using TF-1 Human Erythroleukemic Cells Cell Proliferation Assay Using M‑NFS‑60 Mouse Myelogenous Leukemia Lymphoblast Cells • CSF Family Ligands [11792-HNAH]( Human M-CSF/CSF1 [51112-M08H]( Mouse M-CSF/CSF1 His Tag [90029-C02H]( Cynomolgus M-CSF/CSF1 Fc Tag [10015-H07H]( Human GM-CSF/CSF2 His Tag [51048-M01H]( Mouse GM-CSF/CSF2 Fc Tag [80020-R07H]( Rat GM-CSF/CSF2 His Tag [10007-H01H]( Human G-CSF/CSF3 Fc Tag [10007-HNAH]( Human G-CSF/CSF3 Isoform b [11858-H08B]( Human IL-3 His Tag [80235-R08B]( Rat IL-3 His Tag [51066-MNAH]( Mouse IL-3 More Proteins of CSF Family Ligands [M-CSF/CSF1]( [GM-CSF/CSF2]( [G-CSF/CSF3]( [IL-3]( • CSF Family Receptors [10161-HCCH]( Human CSF1R/CD115 [10161-H08H1]( Human CSF1R/CD115 Domain I&II&III [10161-H08H3]( Human CSF1R/CD115 Domain Ⅳ&Ⅴ [50059-M08H]( Mouse CSF1R/CD115 His Tag [80447-R02H]( Rat CSF1R/CD115 Fc Tag [10218-HCCH]( Human G-CSFR/CD114 [10701-H02H]( Human CSF2RA/CD116 Fc Tag [10516-H08H]( Human CSF2RB/CD131 His Tag [80323-R02H]( Rat CSF2RB/CD131 Fc Tag [10518-H02H]( Human IL3RA/CD123 Fc Tag [50810-M08H]( Mouse IL3RA/CD123 His Tag [70077-D08H]( Canine IL3RA/CD123 His Tag More Proteins of CSF Family Receptors [CSF1R/CD115]( [CSF2RA/CD116]( [CSF2RB/CD131]( [IL3RA/CD123]( CSF/CSFR Antibodies Sino Biological has developed a comprehensive panel of antibodies targeting CSF growth factors and receptors, which can be used in FCM, ELISA, and WB. Human and mouse CSF ELISA kits and ELISA pair sets are also available. Antibody List of CSFs and CSFR [M-CSF/CSF1]( [GM-CSF/CSF2]( [G-CSF/CSF3]( [IL-3]( [CSF1R/CD115]( [CSF2RA/CD116]( [CSF2RB/CD131]( [IL3RA/CD123]( [Sino Biological]( Sino Biological US Inc.[Tel:]+1-215-583-7898 [Order:][order_us@sinobiologicalus.com]( Service:][cro_us@sinobiologicalus.com]( Liberty Ridge Drive, Suite 101, Wayne, PA 19087 [Future Logo] © Future US, Inc., 11 W 42nd Street, 15th Floor, New York, NY 10036. This email is intended for {EMAIL} To unsubscribe from Live Science emails or update your email preferences, please [click here](. [Privacy Policy]( | [Cookies Policy]( | [Terms and Conditions](