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PNAS Table of Contents for 1 August 2017; Vol. 114, No. 31

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This Week in PNAS --------------------------------------------------------------- Letters Michael A.

[PNAS][Proceedings of the National Academy of Sciences] /content/current/content/multimedia/site/authors/index.xhtml/site/aboutpnas/index.xhtml/site/misc/collectedpapers.xhtml/search/content/early/recent [Call for Scocial Sciences papers](/cgi/adclick/?ad=51443&adclick=true&url=http%3A%2F%2Fwww.pnascentral.org) [Proceedings of the National Academy of Sciences](?etoc) [1 August 2017; Vol. 114, No. 31]( ) This Week in PNAS [In This Issue]( --------------------------------------------------------------- Letters (Online Only) [Statistical reanalysis of natural products reveals increasing chemical diversity]( Michael A. Skinnider and Nathan A. Magarvey [Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high]( Cameron R. Pye, Matthew J. Bertin, R. Scott Lokey, William H. Gerwick, and Roger G. Linington [Overfishing causes frequent fish population collapses but rare extinctions]( Olivier Le Pape, Sylvain Bonhommeau, Anne-Elise Nieblas, and Jean-Marc Fromentin [Reply to Le Pape et al.: Management is key to preventing marine extinctions]( Matthew G. Burgess, Alexa Fredston-Hermann, Malin L. Pinsky, Steven D. Gaines, and David Tilman --------------------------------------------------------------- Opinion [Opinion: Finding the plot in science storytelling in hopes of enhancing science communication]( [Front Matter Article] Susana Martinez-Conde and Stephen L. Macknik Leading scientists discuss current issues. --------------------------------------------------------------- QnAs [QnAs with Liqun Luo]( Paul Gabrielsen --------------------------------------------------------------- Profile [Profile of Christine Petit]( Tinsley H. Davis --------------------------------------------------------------- Commentaries [Whether the hearing brain hears it or the deaf brain sees it, it’s just the same]( Marcin Szwed, Łukasz Bola, and Maria Zimmermann [Designing toughness and strength for soft materials]( Xuanhe Zhao [Which way to low-density liquid water?]( Francesco Sciortino --------------------------------------------------------------- PNAS Plus Significance Statements [PNAS Plus Significance Statements]( Brief statements written by the authors about the significance of their papers. --------------------------------------------------------------- Perspective [On the promotion of human flourishing]( [Open Access Article] Tyler J. VanderWeele --------------------------------------------------------------- Physical Sciences Applied Mathematics [Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy]( Syndi Barish, Michael F. Ochs, Eduardo D. Sontag, and Jana L. Gevertz Biophysics and Computational Biology [Activation and synchronization of the oscillatory morphodynamics in multicellular monolayer]( Shao-Zhen Lin, Bo Li, Ganhui Lan, and Xi-Qiao Feng Chemistry [Bioinspired supramolecular fibers drawn from a multiphase self-assembled hydrogel]( [From the Cover] Yuchao Wu, Darshil U. Shah, Chenyan Liu, Ziyi Yu, Ji Liu, Xiaohe Ren, Matthew J. Rowland, Chris Abell, Michael H. Ramage, and Oren A. Scherman Computer Sciences [De novo peptide sequencing by deep learning]( [Open Access Article] Ngoc Hieu Tran, Xianglilan Zhang, Lei Xin, Baozhen Shan, and Ming Li Earth, Atmospheric, and Planetary Sciences [Reassessing the atmospheric oxidation mechanism of toluene]( [Open Access Article] Yuemeng Ji, Jun Zhao, Hajime Terazono, Kentaro Misawa, Nicholas P. Levitt, Yixin Li, Yun Lin, Jianfei Peng, Yuan Wang, Lian Duan, Bowen Pan, Fang Zhang, Xidan Feng, Taicheng An, Wilmarie Marrero-Ortiz, Jeremiah Secrest, Annie L. Zhang, Kazuhiko Shibuya, Mario J. Molina, and Renyi Zhang [Catalysis and chemical mechanisms of calcite dissolution in seawater]( Adam V. Subhas, Jess F. Adkins, Nick E. Rollins, John Naviaux, Jonathan Erez, and William M. Berelson [Thermodynamic constraint on the depth of the global tropospheric circulation]( [Open Access Article] David W. J. Thompson, Sandrine Bony, and Ying Li [Dynamic fluid connectivity during steady-state multiphase flow in a sandstone]( [Open Access Article] Catriona A. Reynolds, Hannah Menke, Matthew Andrew, Martin J. Blunt, and Samuel Krevor Physics [Diffusive dynamics during the high-to-low density transition in amorphous ice]( [Open Access Article] [From the Cover] Fivos Perakis, Katrin Amann-Winkel, Felix Lehmkühler, Michael Sprung, Daniel Mariedahl, Jonas A. Sellberg, Harshad Pathak, Alexander Späh, Filippo Cavalca, Daniel Schlesinger, Alessandro Ricci, Avni Jain, Bernhard Massani, Flora Aubree, Chris J. Benmore, Thomas Loerting, Gerhard Grübel, Lars G. M. Pettersson, and Anders Nilsson --------------------------------------------------------------- Social Sciences Psychological and Cognitive Sciences [Infants possess an abstract expectation of ingroup support]( Kyong-sun Jin and Renée Baillargeon [Support for redistribution is shaped by compassion, envy, and self-interest, but not a taste for fairness]( Daniel Sznycer, Maria Florencia Lopez Seal, Aaron Sell, Julian Lim, Roni Porat, Shaul Shalvi, Eran Halperin, Leda Cosmides, and John Tooby Sustainability Science [Global analysis of depletion and recovery of seabed biota after bottom trawling disturbance]( [Open Access Article] Jan Geert Hiddink, Simon Jennings, Marija Sciberras, Claire L. Szostek, Kathryn M. Hughes, Nick Ellis, Adriaan D. Rijnsdorp, Robert A. McConnaughey, Tessa Mazor, Ray Hilborn, Jeremy S. Collie, C. Roland Pitcher, Ricardo O. Amoroso, Ana M. Parma, Petri Suuronen, and Michel J. Kaiser --------------------------------------------------------------- Biological Sciences Anthropology [Accurate age estimation in small-scale societies]( [Open Access Article] Yoan Diekmann, Daniel Smith, Pascale Gerbault, Mark Dyble, Abigail E. Page, Nikhil Chaudhary, Andrea Bamberg Migliano, and Mark G. Thomas Biochemistry [Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2]( Andrea Piserchio, Mangalika Warthaka, Tamer S. Kaoud, Kari Callaway, Kevin N. Dalby, and Ranajeet Ghose [Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain]( [Open Access Article] Yuri Kato, Miki Hiasa, Reiko Ichikawa, Nao Hasuzawa, Atsushi Kadowaki, Ken Iwatsuki, Kazuhiro Shima, Yasuo Endo, Yoshiro Kitahara, Tsuyoshi Inoue, Masatoshi Nomura, Hiroshi Omote, Yoshinori Moriyama, and Takaaki Miyaji [Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines]( Adrian O. Olivares, Hema Chandra Kotamarthi, Benjamin J. Stein, Robert T. Sauer, and Tania A. Baker [X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway]( Katsuhiko S. Murakami, Yeonoh Shin, Charles L. Turnbough Jr., and Vadim Molodtsov [Nitric oxide is an obligate bacterial nitrification intermediate produced by hydroxylamine oxidoreductase]( Jonathan D. Caranto and Kyle M. Lancaster [Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody]( Andrii Ishchenko, Daniel Wacker, Mili Kapoor, Ai Zhang, Gye Won Han, Shibom Basu, Nilkanth Patel, Marc Messerschmidt, Uwe Weierstall, Wei Liu, Vsevolod Katritch, Bryan L. Roth, Raymond C. Stevens, and Vadim Cherezov [Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin]( Wenyue Guan, Romain Guyot, Jacques Samarut, Frédéric Flamant, Jiemin Wong, and Karine Cécile Gauthier [Molecular mechanism of environmental d-xylose perception by a XylFII-LytS complex in bacteria]( Jianxu Li, Chengyuan Wang, Gaohua Yang, Zhe Sun, Hui Guo, Kai Shao, Yang Gu, Weihong Jiang, and Peng Zhang [Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule]( Md. Faiz Ahmad, Intekhab Alam, Sarah E. Huff, John Pink, Sheryl A. Flanagan, Donna Shewach, Tessianna A. Misko, Nancy L. Oleinick, William E. Harte, Rajesh Viswanathan, Michael E. Harris, and Chris Godfrey Dealwis Biophysics and Computational Biology [Symmetry-related proton transfer pathways in respiratory complex I]( Andrea Di Luca, Ana P. Gamiz-Hernandez, and Ville R. I. Kaila [Sequential eviction of crowded nucleoprotein complexes by the exonuclease RecBCD molecular motor]( Tsuyoshi Terakawa, Sy Redding, Timothy D. Silverstein, and Eric C. Greene [Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B]( Patricia Santofimia-Castaño, Bruno Rizzuti, Ángel L. Pey, Philippe Soubeyran, Miguel Vidal, Raúl Urrutia, Juan L. Iovanna, and José L. Neira [Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements]( [Open Access Article] Gustavo Fuertes, Niccolò Banterle, Kiersten M. Ruff, Aritra Chowdhury, Davide Mercadante, Christine Koehler, Michael Kachala, Gemma Estrada Girona, Sigrid Milles, Ankur Mishra, Patrick R. Onck, Frauke Gräter, Santiago Esteban-Martín, Rohit V. Pappu, Dmitri I. Svergun, and Edward A. Lemke [De novo peptide sequencing by deep learning]( [Open Access Article] Ngoc Hieu Tran, Xianglilan Zhang, Lei Xin, Baozhen Shan, and Ming Li [The case for defined protein folding pathways]( [Open Access Article] [From the Cover] S. Walter Englander and Leland Mayne [Subunit conformational variation within individual GroEL oligomers resolved by Cryo-EM]( [Open Access Article] Soung-Hun Roh, Corey F. Hryc, Hyun-Hwan Jeong, Xue Fei, Joanita Jakana, George H. Lorimer, and Wah Chiu [Combining experimental and simulation data of molecular processes via augmented Markov models]( Simon Olsson, Hao Wu, Fabian Paul, Cecilia Clementi, and Frank Noé Cell Biology [VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia]( Juan-Juan Zhu, Yue-Feng Liu, Yun-Peng Zhang, Chuan-Rong Zhao, Wei-Juan Yao, Yi-Shuan Li, Kuei-Chun Wang, Tse-Shun Huang, Wei Pang, Xi-Fu Wang, Xian Wang, Shu Chien, and Jing Zhou [MitoNEET-dependent formation of intermitochondrial junctions]( [Open Access Article] Alexandre Vernay, Anna Marchetti, Ayman Sabra, Tania N. Jauslin, Manon Rosselin, Philipp E. Scherer, Nicolas Demaurex, Lelio Orci, and Pierre Cosson [Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels]( Jun Liu, Yong Juan Zhao, Wan Hua Li, Yun Nan Hou, Ting Li, Zhi Ying Zhao, Cheng Fang, Song Lu Li, and Hon Cheung Lee Developmental Biology [Conserved gene regulatory module specifies lateral neural borders across bilaterians]( Yongbin Li, Di Zhao, Takeo Horie, Geng Chen, Hongcun Bao, Siyu Chen, Weihong Liu, Ryoko Horie, Tao Liang, Biyu Dong, Qianqian Feng, Qinghua Tao, and Xiao Liu [Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells]( Yohei Hayashi, Kei Otsuka, Masayuki Ebina, Kaori Igarashi, Asuka Takehara, Mitsuyo Matsumoto, Akio Kanai, Kazuhiko Igarashi, Tomoyoshi Soga, and Yasuhisa Matsui [Broadly expressed repressors integrate patterning across orthogonal axes in embryos]( Theodora Koromila and Angelike Stathopoulos Ecology [Global analysis of depletion and recovery of seabed biota after bottom trawling disturbance]( [Open Access Article] Jan Geert Hiddink, Simon Jennings, Marija Sciberras, Claire L. Szostek, Kathryn M. Hughes, Nick Ellis, Adriaan D. Rijnsdorp, Robert A. McConnaughey, Tessa Mazor, Ray Hilborn, Jeremy S. Collie, C. Roland Pitcher, Ricardo O. Amoroso, Ana M. Parma, Petri Suuronen, and Michel J. Kaiser [Canopy structure drives orangutan habitat selection in disturbed Bornean forests]( Andrew B. Davies, Marc Ancrenaz, Felicity Oram, and Gregory P. Asner [Nuclear genomes distinguish cryptic species suggested by their DNA barcodes and ecology]( Daniel H. Janzen, John M. Burns, Qian Cong, Winnie Hallwachs, Tanya Dapkey, Ramya Manjunath, Mehrdad Hajibabaei, Paul D. N. Hebert, and Nick V. Grishin Environmental Sciences [Cryptic oxygen cycling in anoxic marine zones]( Emilio Garcia-Robledo, Cory C. Padilla, Montserrat Aldunate, Frank J. Stewart, Osvaldo Ulloa, Aurélien Paulmier, Gerald Gregori, and Niels Peter Revsbech Evolution [Insights into the red algae and eukaryotic evolution from the genome of Porphyra umbilicalis (Bangiophyceae, Rhodophyta)]( [Open Access Article] Susan H. Brawley, Nicolas A. Blouin, Elizabeth Ficko-Blean, Glen L. Wheeler, Martin Lohr, Holly V. Goodson, Jerry W. Jenkins, Crysten E. Blaby-Haas, Katherine E. Helliwell, Cheong Xin Chan, Tara N. Marriage, Debashish Bhattacharya, Anita S. Klein, Yacine Badis, Juliet Brodie, Yuanyu Cao, Jonas Collén, Simon M. Dittami, Claire M. M. Gachon, Beverley R. Green, Steven J. Karpowicz, Jay W. Kim, Ulrich Johan Kudahl, Senjie Lin, Gurvan Michel, Maria Mittag, Bradley J. S. C. Olson, Jasmyn L. Pangilinan, Yi Peng, Huan Qiu, Shengqiang Shu, John T. Singer, Alison G. Smith, Brittany N. Sprecher, Volker Wagner, Wenfei Wang, Zhi-Yong Wang, Juying Yan, Charles Yarish, Simone Zäuner-Riek, Yunyun Zhuang, Yong Zou, Erika A. Lindquist, Jane Grimwood, Kerrie W. Barry, Daniel S. Rokhsar, Jeremy Schmutz, John W. Stiller, Arthur R. Grossman, and Simon E. Prochnik [Polymorphism at a mimicry supergene maintained by opposing frequency-dependent selection pressures]( [From the Cover] Mathieu Chouteau, Violaine Llaurens, Florence Piron-Prunier, and Mathieu Joron [Hitchhiking and epistasis give rise to cohort dynamics in adapting populations]( [Open Access Article] Sean W. Buskirk, Ryan Emily Peace, and Gregory I. Lang Genetics [Toll ligand Spätzle3 controls melanization in the stripe pattern formation in caterpillars]( Yûsuke KonDo, Shinichi Yoda, Takayuki Mizoguchi, Toshiya Ando, Junichi Yamaguchi, Kimiko Yamamoto, Yutaka Banno, and Haruhiko Fujiwara [Severe viral respiratory infections in children with IFIH1 loss-of-function mutations]( [Open Access Article] Samira Asgari, Luregn J. Schlapbach, Stéphanie Anchisi, Christian Hammer, Istvan Bartha, Thomas Junier, Geneviève Mottet-Osman, Klara M. Posfay-Barbe, David Longchamp, Martin Stocker, Samuel Cordey, Laurent Kaiser, Thomas Riedel, Tony Kenna, Deborah Long, Andreas Schibler, Amalio Telenti, Caroline Tapparel, Paul J. McLaren, Dominique Garcin, and Jacques Fellay Immunology and Inflammation [Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+ dendritic cells]( Vrajesh V. Parekh, Sudheer K. Pabbisetty, Lan Wu, Eric Sebzda, Jennifer Martinez, Jianhua Zhang, and Luc Van Kaer [Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy]( [Open Access Article] Nikolaos I. Kyratsous, Isabel J. Bauer, Guokun Zhang, Marija Pesic, Ingo Bartholomäus, Marsilius Mues, Ping Fang, Miriam Wörner, Stephanie Everts, Joachim W. Ellwart, Joanna M. Watt, Barry V. L. Potter, Reinhard Hohlfeld, Hartmut Wekerle, and Naoto Kawakami [Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis]( [Open Access Article] Ravi Shankar Keshari, Robert Silasi, Narcis Ioan Popescu, Maulin Mukeshchandra Patel, Hala Chaaban, Cristina Lupu, K. Mark Coggeshall, Tom Eirik Mollnes, Steven J. DeMarco, and Florea Lupu [A distinct subpopulation of CD25− T-follicular regulatory cells localizes in the germinal centers]( James Badger Wing, Yohko Kitagawa, Michela Locci, Hannah Hume, Christopher Tay, Takayoshi Morita, Yujiro Kidani, Kyoko Matsuda, Takeshi Inoue, Tomohiro Kurosaki, Shane Crotty, Cevayir Coban, Naganari Ohkura, and Shimon Sakaguchi [Structural determination of lipid antigens captured at the CD1d–T-cell receptor interface]( Patrick J. Brennan, Tan-Yun Cheng, Daniel G. Pellicci, Gerald F. M. Watts, Natacha Veerapen, David C. Young, Jamie Rossjohn, Gurdyal S. Besra, Dale I. Godfrey, Michael B. Brenner, and D. Branch Moody [BRCT-domain protein BRIT1 influences class switch recombination]( Wei-Feng Yen, Ashutosh Chaudhry, Bharat Vaidyanathan, William T. Yewdell, Joseph N. Pucella, Rahul Sharma, Yulong Liang, Kaiyi Li, Alexander Y. Rudensky, and Jayanta Chaudhuri Medical Sciences [Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells]( Yun Li, Jianxin Fu, Yun Ling, Tadayuki Yago, J. Michael McDaniel, Jianhua Song, Xia Bai, Yuji Kondo, Yannan Qin, Christopher Hoover, Samuel McGee, Bojing Shao, Zhenghui Liu, Roberto Sonon, Parastoo Azadi, Jamey D. Marth, Rodger P. McEver, Changgeng Ruan, and Lijun Xia [Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A]( Wei Wang, Honghong Zhang, Sali Liu, Chung Kwon Kim, Yilin Xu, Lisa A. Hurley, Ryo Nishikawa, Motoo Nagane, Bo Hu, Alexander H. Stegh, Shi-Yuan Cheng, and Chonghui Cheng [Bacterial infection imaging with [18F]fluoropropyl-trimethoprim]( Mark A. Sellmyer, Iljung Lee, Catherine Hou, Chi-Chang Weng, Shihong Li, Brian P. Lieberman, Chenbo Zeng, David A. Mankoff, and Robert H. Mach Microbiology [Virus found in a boreal lake links ssDNA and dsDNA viruses]( Elina Laanto, Sari Mäntynen, Luigi De Colibus, Jenni Marjakangas, Ashley Gillum, David I. Stuart, Janne J. Ravantti, Juha T. Huiskonen, and Lotta-Riina Sundberg [Antibody-based assay discriminates Zika virus infection from other flaviviruses]( [Open Access Article] Angel Balmaseda, Karin Stettler, Raquel Medialdea-Carrera, Damaris Collado, Xia Jin, José Victor Zambrana, Stefano Jaconi, Elisabetta Cameroni, Saira Saborio, Francesca Rovida, Elena Percivalle, Samreen Ijaz, Steve Dicks, Ines Ushiro-Lumb, Luisa Barzon, Patricia Siqueira, David W. G. Brown, Fausto Baldanti, Richard Tedder, Maria Zambon, A. M. Bispo de Filippis, Eva Harris, and Davide Corti Neuroscience [Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate]( Haixia Gao, Aurélien Boillat, Dongyang Huang, Ce Liang, Chris Peers, and Nikita Gamper [Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury]( [Open Access Article] Austin Chou, Karen Krukowski, Timothy Jopson, Ping Jun Zhu, Mauro Costa-Mattioli, Peter Walter, and Susanna Rosi [Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence]( Sophie E. Holmes, Matthew J. Girgenti, Margaret T. Davis, Robert H. Pietrzak, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Steven Southwick, Ronald S. Duman, Richard E. Carson, John H. Krystal, Irina Esterlis, and the Traumatic Stress Brain Study Group Pharmacology [Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice]( [Open Access Article] Miguel A. Tejada, Angeles Montilla-García, Shane J. Cronin, Domagoj Cikes, Cristina Sánchez-Fernández, Rafael González-Cano, M. Carmen Ruiz-Cantero, Josef M. Penninger, José M. Vela, José M. Baeyens, and Enrique J. Cobos Physiology [Prostaglandin dehydrogenase is a target for successful induction of cervical ripening]( Annavarapu Hari Kishore, Hanquan Liang, Mohammed Kanchwala, Chao Xing, Thota Ganesh, Yucel Akgul, Bruce Posner, Joseph M. Ready, Sanford D. Markowitz, and Ruth Ann Word [Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy]( [Open Access Article] Nigel F. Delaney, Rohit Sharma, Laura Tadvalkar, Clary B. Clish, Ronald G. Haller, and Vamsi K. Mootha [Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland]( Cristina Sáenz de Miera, Béatrice Bothorel, Catherine Jaeger, Valérie Simonneaux, and David Hazlerigg Plant Biology [Nucleoredoxin guards against oxidative stress by protecting antioxidant enzymes]( [Open Access Article] Sophie Kneeshaw, Rumana Keyani, Valérie Delorme-Hinoux, Lisa Imrie, Gary J. Loake, Thierry Le Bihan, Jean-Philippe Reichheld, and Steven H. Spoel Psychological and Cognitive Sciences [Functional selectivity for face processing in the temporal voice area of early deaf individuals]( [Open Access Article] Stefania Benetti, Markus J. van Ackeren, Giuseppe Rabini, Joshua Zonca, Valentina Foa, Francesca Baruffaldi, Mohamed Rezk, Francesco Pavani, Bruno Rossion, and Olivier Collignon [Support for redistribution is shaped by compassion, envy, and self-interest, but not a taste for fairness]( Daniel Sznycer, Maria Florencia Lopez Seal, Aaron Sell, Julian Lim, Roni Porat, Shaul Shalvi, Eran Halperin, Leda Cosmides, and John Tooby [Body ownership determines the attenuation of self-generated tactile sensations]( [Open Access Article] Konstantina Kilteni and H. Henrik Ehrsson Systems Biology [Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy]( Syndi Barish, Michael F. Ochs, Eduardo D. Sontag, and Jana L. Gevertz [Diverse continuum of CD4+ T-cell states is determined by hierarchical additive integration of cytokine signals]( Inbal Eizenberg-Magar, Jacob Rimer, Irina Zaretsky, David Lara-Astiaso, Shlomit Reich-Zeliger, and Nir Friedman [Cellular trade-offs and optimal resource allocation during cyanobacterial diurnal growth]( Alexandra-M. Reimers, Henning Knoop, Alexander Bockmayr, and Ralf Steuer [Dynamic responses of the adrenal steroidogenic regulatory network]( [Open Access Article] Francesca Spiga, Eder Zavala, Jamie J. Walker, Zidong Zhao, John R. Terry, and Stafford L. Lightman --------------------------------------------------------------- Correction (Online Only) [Correction for Wu et al., Multiensemble Markov models of molecular thermodynamics and kinetics]( [Cover] Open Access From the Cover Inaugural Article Classic Cozzarelli Prize Winner Front Matter --------------------------------------------------------------- This message was sent to {EMAIL}. 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