PNAS Table of Contents for February 15, 2022; Vol. 119, No. 7 is now complete

[PNAS] [The PNAS Highlights Newsletter: Sign up now.](/cgi/adclick/?ad=56412&adclick=true&url=http%3A%2F%2Feepurl.com%2FgymAfD)   [February 15, 2022; Vol. 119, No. 7]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- News Feature [News Feature: Climate change hastens disease spread across the globe]( Amy McDermott An in-depth look at trending science issues --------------------------------------------------------------- QnAs [QnAs with David Van Essen]( Sandeep Ravindran Interviews with leading scientific researchers and newsmakers --------------------------------------------------------------- Commentaries [Casting a bright light on Ostwald’s rule of stages]( James J. De Yoreo [In vivo oxidation by thioredoxin regulates chloroplast enzymes activity]( Alizée Malnoë [Soft colloids for complex interfacial assemblies]( Fabrizio Camerin and Emanuela Zaccarelli --------------------------------------------------------------- Perspective [Ten facts about land systems for sustainability]( Patrick Meyfroidt, Ariane de Bremond, Casey M. Ryan, Emma Archer, Richard Aspinall, Abha Chhabra, Gilberto Camara, Esteve Corbera, Ruth DeFries, Sandra Díaz, Jinwei Dong, Erle C. Ellis, Karl-Heinz Erb, Janet A. Fisher, Rachael D. Garrett, Nancy E. Golubiewski, H. Ricardo Grau, J. Morgan Grove, Helmut Haberl, Andreas Heinimann, Patrick Hostert, Esteban G. Jobbágy, Suzi Kerr, Tobias Kuemmerle, Eric F. Lambin, Sandra Lavorel, Sharachandra Lele, Ole Mertz, Peter Messerli, Graciela Metternicht, Darla K. Munroe, Harini Nagendra, Jonas Østergaard Nielsen, Dennis S. Ojima, Dawn Cassandra Parker, Unai Pascual, John R. Porter, Navin Ramankutty, Anette Reenberg, Rinku Roy Chowdhury, Karen C. Seto, Verena Seufert, Hideaki Shibata, Allison Thomson, Billie L. Turner II, Jotaro Urabe, Tom Veldkamp, Peter H. Verburg, Gete Zeleke, and Erasmus K. H. J. zu Ermgassen --------------------------------------------------------------- Letters [Only extraordinary volcanism can explain the presence of parts per billion phosphine on Venus]( William Bains, Oliver Shorttle, Sukrit Ranjan, Paul B. Rimmer, Janusz J. Petkowski, Jane S. Greaves, and Sara Seager [Reply to Bains et al.: On the plausibility of crustal phosphides as the source of Venusian phosphine]( Ngoc Truong and Jonathan I. Lunine [Reply to Gremese et al.: Statistical reasoning to evaluate treatment effects when data are collected with lack of design: Covid-19 experience]( Clelia Di Serio, Pietro Cippà, Alessandro Ceschi, and Paolo Ferrari --------------------------------------------------------------- Brief Report [Self-reported COVID-19 infection and implications for mental health and food insecurity among American college students]( Sara Goldrick-Rab, Vanessa Coca, Japbir Gill, Morgan Peele, Kallie Clark, and Elizabeth Looker --------------------------------------------------------------- Physical Sciences Applied Physical Sciences [Nucleation of glucose isomerase protein crystals in a nonclassical disguise: The role of crystalline precursors]( Alexander E. S. Van Driessche, Wai Li Ling, Guy Schoehn, and Mike Sleutel [Fracture of model end-linked networks]( Christopher W. Barney, Ziyu Ye, Ipek Sacligil, Kelly R. McLeod, Han Zhang, Gregory N. Tew, Robert A. Riggleman, and Alfred J. Crosby Biophysics and Computational Biology [Scale-dependent tipping points of bacterial colonization resistance]( Yuya Karita, David T. Limmer, and Oskar Hallatschek [A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics]( Ola Karmi, Henri-Baptiste Marjault, Fang Bai, Susmita Roy, Yang-Sung Sohn, Merav Darash Yahana, Faruck Morcos, Konstantinos Ioannidis, Yaakov Nahmias, Patricia A. Jennings, Ron Mittler, José N. Onuchic, and Rachel Nechushtai [Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase]( Chul-Jin Lee, Robyn Stix, Mitra S. Rana, Flowreen Shikwana, R. Elliot Murphy, Rodolfo Ghirlando, José D. Faraldo-Gómez, and Anirban Banerjee [Enhancing computational enzyme design by a maximum entropy strategy]( Wen Jun Xie, Mojgan Asadi, and Arieh Warshel [Evolution during primary HIV infection does not require adaptive immune selection]( David A. Swan, Morgane Rolland, Joshua T. Herbeck, Joshua T. Schiffer, and Daniel B. Reeves Chemistry [Steering CO2 hydrogenation toward C–C coupling to hydrocarbons using porous organic polymer/metal interfaces]( Chengshuang Zhou, Arun S. Asundi, Emmett D. Goodman, Jiyun Hong, Baraa Werghi, Adam S. Hoffman, Sindhu S. Nathan, Stacey F. Bent, Simon R. Bare, and Matteo Cargnello [A minimal cage of a diamond twin with chirality]( Toshiya M. Fukunaga, Takahide Kato, Koki Ikemoto, and Hiroyuki Isobe Earth, Atmospheric, and Planetary Sciences [The influence of iodine on the Antarctic stratospheric ozone hole]( Carlos A. Cuevas, Rafael P. Fernandez, Douglas E. Kinnison, Qinyi Li, Jean-François Lamarque, Tarek Trabelsi, Joseph S. Francisco, Susan Solomon, and Alfonso Saiz-Lopez Engineering [Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer]( Na Kong, Ruonan Zhang, Gongwei Wu, Xinbing Sui, Junqing Wang, Na Yoon Kim, Sara Blake, Diba De, Tian Xie, Yihai Cao, and Wei Tao Physics [Intertwined spin, charge, and pair correlations in the two-dimensional Hubbard model in the thermodynamic limit]( Peizhi Mai, Seher Karakuzu, Giovanni Balduzzi, Steven Johnston, and Thomas A. Maier [A perfect X-ray beam splitter and its applications to time-domain interferometry and quantum optics exploiting free-electron lasers]( Sven Reiche, Gregor Knopp, Bill Pedrini, Eduard Prat, Gabriel Aeppli, and Simon Gerber --------------------------------------------------------------- Social Sciences Psychological and Cognitive Sciences [Disentangling the individual and contextual effects of math anxiety: A global perspective]( Nathan T. T. Lau, Zachary Hawes, Paul Tremblay, and Daniel Ansari Social Sciences [Trends in social mobility in postrevolution China]( Yu Xie, Hao Dong, Xiang Zhou, and Xi Song [Middle Eastern and North African Americans may not be perceived, nor perceive themselves, to be White]( Neda Maghbouleh, Ariela Schachter, and René D. Flores Sustainability Science [Land-use trajectories for sustainable land system transformations: Identifying leverage points in a global biodiversity hotspot]( Dominic Andreas Martin, Fanilo Andrianisaina, Thio Rosin Fulgence, Kristina Osen, Anjaharinony Andry Ny Aina Rakotomalala, Estelle Raveloaritiana, Marie Rolande Soazafy, Annemarie Wurz, Rouvah Andriafanomezantsoa, Harilala Andriamaniraka, Aristide Andrianarimisa, Jan Barkmann, Saskia Dröge, Ingo Grass, Nathaly Guerrero-Ramirez, Hendrik Hänke, Dirk Hölscher, Bakolimalala Rakouth, Hery Lisy Tiana Ranarijaona, Romual Randriamanantena, Fanomezana Mihaja Ratsoavina, Lala Harivelo Raveloson Ravaomanarivo, Dominik Schwab, Teja Tscharntke, Delphine Clara Zemp, and Holger Kreft --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Metabolomic selection for enhanced fruit flavor]( Vincent Colantonio, Luis Felipe V. Ferrão, Denise M. Tieman, Nikolay Bliznyuk, Charles Sims, Harry J. Klee, Patricio Munoz, and Marcio F. R. Resende Jr. [Persistent soil carbon enhanced in Mollisols by well-managed grasslands but not annual grain or dairy forage cropping systems]( Yichao Rui, Randall D. Jackson, M. Francesca Cotrufo, Gregg R. Sanford, Brian J. Spiesman, Leonardo Deiss, Steven W. Culman, Chao Liang, and Matthew D. Ruark Applied Biological Sciences [Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer]( Na Kong, Ruonan Zhang, Gongwei Wu, Xinbing Sui, Junqing Wang, Na Yoon Kim, Sara Blake, Diba De, Tian Xie, Yihai Cao, and Wei Tao Biochemistry [Nucleation of glucose isomerase protein crystals in a nonclassical disguise: The role of crystalline precursors]( Alexander E. S. Van Driessche, Wai Li Ling, Guy Schoehn, and Mike Sleutel [Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase]( Chul-Jin Lee, Robyn Stix, Mitra S. Rana, Flowreen Shikwana, R. Elliot Murphy, Rodolfo Ghirlando, José D. Faraldo-Gómez, and Anirban Banerjee [Munc13 structural transitions and oligomers that may choreograph successive stages in vesicle priming for neurotransmitter release]( Kirill Grushin, R. Venkat Kalyana Sundaram, Charles V. Sindelar, and James E. Rothman [Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling]( Rushita A. Bagchi, Emma L. Robinson, Tianjing Hu, Ji Cao, Jun Young Hong, Charles A. Tharp, Hanan Qasim, Kathleen M. Gavin, Julie Pires da Silva, Jennifer L. Major, Bradley K. McConnell, Edward Seto, Hening Lin, and Timothy A. McKinsey [Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells]( Yuta Ryoden, Katsumori Segawa, and Shigekazu Nagata [Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides]( Aleksandar Radakovic, Saurja DasGupta, Tom H. Wright, Harry R. M. Aitken, and Jack W. Szostak Biophysics and Computational Biology [Enhancing computational enzyme design by a maximum entropy strategy]( Wen Jun Xie, Mojgan Asadi, and Arieh Warshel [A perfect X-ray beam splitter and its applications to time-domain interferometry and quantum optics exploiting free-electron lasers]( Sven Reiche, Gregor Knopp, Bill Pedrini, Eduard Prat, Gabriel Aeppli, and Simon Gerber [The pathogenic R5L mutation disrupts formation of Tau complexes on the microtubule by altering local N-terminal structure]( Alisa Cario, Adriana Savastano, Neil B. Wood, Zhu Liu, Michael J. Previs, Adam G. Hendricks, Markus Zweckstetter, and Christopher L. Berger [Real-time pandemic surveillance using hospital admissions and mobility data]( Spencer J. Fox, Michael Lachmann, Mauricio Tec, Remy Pasco, Spencer Woody, Zhanwei Du, Xutong Wang, Tanvi A. Ingle, Emily Javan, Maytal Dahan, Kelly Gaither, Mark E. Escott, Stephen I. Adler, S. Claiborne Johnston, James G. Scott, and Lauren Ancel Meyers [Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P2 and rapamycin]( Ninghai Gan, Yan Han, Weizhong Zeng, Yan Wang, Jing Xue, and Youxing Jiang Cell Biology [TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation]( Di Liu, Zhiyao Zhao, Yuanchu She, Lei Zhang, Xiangtian Chen, Ling Ma, and Jun Cui [Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly]( Krishnendu Khan, Briana Long, Camelia Baleanu-Gogonea, Valentin Gogonea, Gauravi M. Deshpande, Kommireddy Vasu, and Paul L. Fox [A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion]( Jingting Qiao, Ziyin Zhang, Shuhui Ji, Tengli Liu, Xiaona Zhang, Yumeng Huang, Wenli Feng, Kunling Wang, Jianyu Wang, Shusen Wang, Zhuo-Xian Meng, and Ming Liu Ecology [Fear of predators in free-living wildlife reduces population growth over generations]( Marek C. Allen, Michael Clinchy, and Liana Y. Zanette [The dynamic trophic architecture of open-ocean protist communities revealed through machine-guided metatranscriptomics]( Bennett S. Lambert, Ryan D. Groussman, Megan J. Schatz, Sacha N. Coesel, Bryndan P. Durham, Andrew J. Alverson, Angelicque E. White, and E. Virginia Armbrust [Scale-dependent tipping points of bacterial colonization resistance]( Yuya Karita, David T. Limmer, and Oskar Hallatschek [Land-use trajectories for sustainable land system transformations: Identifying leverage points in a global biodiversity hotspot]( Dominic Andreas Martin, Fanilo Andrianisaina, Thio Rosin Fulgence, Kristina Osen, Anjaharinony Andry Ny Aina Rakotomalala, Estelle Raveloaritiana, Marie Rolande Soazafy, Annemarie Wurz, Rouvah Andriafanomezantsoa, Harilala Andriamaniraka, Aristide Andrianarimisa, Jan Barkmann, Saskia Dröge, Ingo Grass, Nathaly Guerrero-Ramirez, Hendrik Hänke, Dirk Hölscher, Bakolimalala Rakouth, Hery Lisy Tiana Ranarijaona, Romual Randriamanantena, Fanomezana Mihaja Ratsoavina, Lala Harivelo Raveloson Ravaomanarivo, Dominik Schwab, Teja Tscharntke, Delphine Clara Zemp, and Holger Kreft Environmental Sciences [Vertical stratification of the air microbiome in the lower troposphere]( Daniela I. Drautz-Moses, Irvan Luhung, Elena S. Gusareva, Carmon Kee, Nicolas E. Gaultier, Balakrishnan N. V. Premkrishnan, Choou Fook Lee, See Ting Leong, Changsook Park, Zhei Hwee Yap, Cassie E. Heinle, Kenny J. X. Lau, Rikky W. Purbojati, Serene B. Y. Lim, Yee Hui Lim, Shruti Ketan Kutmutia, Ngu War Aung, Elaine L. Oliveira, Soo Guek Ng, Justine Dacanay, Poh Nee Ang, Samuel D. Spence, Wen Jia Phung, Anthony Wong, Ryan J. Kennedy, Namrata Kalsi, Santhi Puramadathil Sasi, Lakshmi Chandrasekaran, Akira Uchida, Ana Carolina M. Junqueira, Hie Lim Kim, Rudolf Hankers, Thomas Feuerle, Ulrich Corsmeier, and Stephan C. Schuster Evolution [Evolution during primary HIV infection does not require adaptive immune selection]( David A. Swan, Morgane Rolland, Joshua T. Herbeck, Joshua T. Schiffer, and Daniel B. Reeves [Mutation bias shapes the spectrum of adaptive substitutions]( Alejandro V. Cano, Hana Rozhoňová, Arlin Stoltzfus, David M. McCandlish, and Joshua L. Payne [A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals]( David A. Eagles, Natalie J. Saez, Bankala Krishnarjuna, Julia J. Bradford, Yanni K.-Y. Chin, Hana Starobova, Alexander Mueller, Melissa E. Reichelt, Eivind A. B. Undheim, Raymond S. Norton, Walter G. Thomas, Irina Vetter, Glenn F. King, and Samuel D. Robinson Genetics [Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1]( Ena Oreskovic, Emily C. Wheeler, Kristen E. Mengwasser, Eric Fujimura, Timothy D. Martin, Zuzana Tothova, and Stephen J. Elledge [Fungal gasdermin-like proteins are controlled by proteolytic cleavage]( Corinne Clavé, Witold Dyrka, Elizabeth A. Turcotte, Alexandra Granger-Farbos, Léa Ibarlosa, Benoît Pinson, Russell E. Vance, Sven J. Saupe, and Asen Daskalov Immunology and Inflammation [CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory]( Yujiro Kidani, Wataru Nogami, Yoshiaki Yasumizu, Atsunari Kawashima, Atsushi Tanaka, Yudai Sonoda, Yumi Tona, Kunitaka Nashiki, Reimi Matsumoto, Masaki Hagiwara, Motonao Osaki, Keiji Dohi, Takayuki Kanazawa, Azumi Ueyama, Mai Yoshikawa, Tetsuya Yoshida, Mitsunobu Matsumoto, Kanji Hojo, Satomi Shinonome, Hiroshi Yoshida, Michinari Hirata, Miya Haruna, Yamami Nakamura, Daisuke Motooka, Daisuke Okuzaki, Yasuko Sugiyama, Makoto Kinoshita, Tatsusada Okuno, Taigo Kato, Koji Hatano, Motohide Uemura, Ryoichi Imamura, Kazunori Yokoi, Atsushi Tanemura, Yasushi Shintani, Tadashi Kimura, Norio Nonomura, Hisashi Wada, Masaki Mori, Yuichiro Doki, Naganari Ohkura, and Shimon Sakaguchi Microbiology [Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation]( Nathalie Béchon, Jovana Mihajlovic, Anne-Aurélie Lopes, Sol Vendrell-Fernández, Julien Deschamps, Romain Briandet, Odile Sismeiro, Isabelle Martin-Verstraete, Bruno Dupuy, and Jean-Marc Ghigo [Nitric oxide stimulates type IV MSHA pilus retraction in Vibrio cholerae via activation of the phosphodiesterase CdpA]( Hannah Q. Hughes, Kyle A. Floyd, Sajjad Hossain, Sweta Anantharaman, David T. Kysela, Miklόs Zöldi, Lászlό Barna, Yuanchen Yu, Michael P. Kappler, Triana N. Dalia, Ram C. Podicheti, Douglas B. Rusch, Meng Zhuang, Cassandra L. Fraser, Yves V. Brun, Stephen C. Jacobson, James B. McKinlay, Fitnat H. Yildiz, Elizabeth M. Boon, and Ankur B. Dalia [Stochastic microbiome assembly depends on context]( Eric W. Jones, Jean M. Carlson, David A. Sivak, and William B. Ludington [N6-methyladenosine modification of the 5′ epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein]( Geon-Woo Kim, Jae-Su Moon, and Aleem Siddiqui Neuroscience [Self-healing codes: How stable neural populations can track continually reconfiguring neural representations]( Michael E. Rule and Timothy O’Leary [Functional network topography of the medial entorhinal cortex]( Horst A. Obenhaus, Weijian Zong, R. Irene Jacobsen, Tobias Rose, Flavio Donato, Liangyi Chen, Heping Cheng, Tobias Bonhoeffer, May-Britt Moser, and Edvard I. Moser [Consciousness is supported by near-critical slow cortical electrodynamics]( Daniel Toker, Ioannis Pappas, Janna D. Lendner, Joel Frohlich, Diego M. Mateos, Suresh Muthukumaraswamy, Robin Carhart-Harris, Michelle Paff, Paul M. Vespa, Martin M. Monti, Friedrich T. Sommer, Robert T. Knight, and Mark D’Esposito [A diffusion MRI-based spatiotemporal continuum of the embryonic mouse brain for probing gene–neuroanatomy connections]( Dan Wu, Linda J. Richards, Zhiyong Zhao, Zuozhen Cao, Wanrong Luo, Wei Shao, Song-Hai Shi, Michael I. Miller, Susumu Mori, Seth Blackshaw, and Jiangyang Zhang [Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased anxiety]( Erik Smedler, Lauri Louhivuori, Roman A. Romanov, Débora Masini, Ivar Dehnisch Ellström, Chungliang Wang, Martino Caramia, Zoe West, Songbai Zhang, Paola Rebellato, Seth Malmersjö, Irene Brusini, Shigeaki Kanatani, Gilberto Fisone, Tibor Harkany, and Per Uhlén [Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome]( Feng Gu, Isabel Parada, Tao Yang, Frank M. Longo, and David A. Prince [Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma]( Luis Alarcon-Martinez, Yukihiro Shiga, Deborah Villafranca-Baughman, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Jorge L. Cueva Vargas, and Adriana Di Polo [Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination]( Masashi Watanave, Nobutaka Takahashi, Nobutake Hosoi, Ayumu Konno, Hikaru Yamamoto, Hiroyuki Yasui, Mika Kawachi, Takuro Horii, Yasunori Matsuzaki, Izuho Hatada, and Hirokazu Hirai Physiology [Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver]( Lara Bideyan, Wenxin Fan, Karolina Elżbieta Kaczor-Urbanowicz, Christina Priest, David Casero, and Peter Tontonoz [Somatostatin-type and allatostatin-C–type neuropeptides are paralogous and have opposing myoregulatory roles in an echinoderm]( Ya Zhang, Luis Alfonso Yañez-Guerra, Ana B. Tinoco, Nayeli Escudero Castelán, Michaela Egertová, and Maurice R. Elphick Plant Biology [A flavin-dependent monooxygenase produces nitrogenous tomato aroma volatiles using cysteine as a nitrogen source]( David K. Liscombe, Yusuke Kamiyoshihara, Jérémie Ghironzi, Christine J. Kempthorne, Kevin Hooton, Blandine Bulot, Vassili Kanellis, James McNulty, Nghi B. Lam, Louis Félix Nadeau, Michael Pautler, Denise M. Tieman, Harry J. Klee, and Charles Goulet --------------------------------------------------------------- Corrections [Correction for Douglass et al., Late Pleistocene/Early Holocene sites in the montane forests of New Guinea yield early record of cassowary hunting and egg harvesting]( [Correction for Toczydlowski et al., Poor data stewardship will hinder global genetic diversity surveillance]( [Correction for Yang et al., Just 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in communities]( --------------------------------------------------------------- SI Correction [Correction to Supporting Information for Perkins et al., De novo biosynthesis of a nonnatural cobalt porphyrin cofactor in E. coli and incorporation into hemoproteins]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. [Unsubscribe]( from or [edit]( your subscription for this service. 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