PNAS Table of Contents for February 8, 2022; Vol. 119, No. 6 is now complete

[PNAS] [PNAS Nexus: A new open access journal. Find out more.](/cgi/adclick/?ad=56398&adclick=true&url=https%3A%2F%2Fwww.pnas.org%2Fpage%2Fupdates%23nexus-launch)   [February 8, 2022; Vol. 119, No. 6]( ) This Week in PNAS [In This Issue]( This week's research highlights --------------------------------------------------------------- Opinion [Opinion: Wastewater analysis can be a powerful public health tool—if it’s done sensibly]( Hannah R. Safford, Karen Shapiro, and Heather N. Bischel Leading scientists discuss current issues --------------------------------------------------------------- Commentaries [Cellular itinerary of LDL cholesterol]( Jean E. Vance [Countering obesity with eosinophils and sympathetic fat]( Maureen A. Cox [Polymorphism in peptide self-assembly visualized]( Matthew Tirrell --------------------------------------------------------------- Letters [IgG3 constant region GM (γ marker) allotypes could influence the neutralizing potency of anti–SARS-CoV-2 monoclonal antibodies]( Janardan P. Pandey [Reply to Pandey: Possible functional impact of IgG3 allotype constant region]( Somanath Kallolimath, Falk Nimmerjahn, and Herta Steinkellner [Evolution of pinniped UCP1 is not linked to aquatic life but to neonatal thermogenesis and body size]( Michael J. Gaudry, Thomas Jacob Fyda, and Martin Jastroch [Reply to Gaudry et al.: Cross-validation is necessary for the identification of pseudogenes]( Yuan Yuan, Inge Seim, A. Rus Hoelzel, Yaolei Zhang, Peijun Zhang, Hui Kang, Ding Wang, Guangyi Fan, Kun Wang, and Songhai Li --------------------------------------------------------------- Physical Sciences Applied Mathematics [Hierarchical timescales in the neocortex: Mathematical mechanism and biological insights]( Songting Li and Xiao-Jing Wang [Noninvasive inference methods for interaction and noise intensities of coupled oscillators using only spike time data]( Fumito Mori and Hiroshi Kori Applied Physical Sciences [DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor]( Raphael I. Benhamou, Blessy M. Suresh, Yuquan Tong, Wesley G. Cochrane, Valerie Cavett, Simon Vezina-Dawod, Daniel Abegg, Jessica L. Childs-Disney, Alexander Adibekian, Brian M. Paegel, and Matthew D. Disney [Single-molecule optofluidic microsensor with interface whispering gallery modes]( Xiao-Chong Yu, Shui-Jing Tang, Wenjing Liu, Yinglun Xu, Qihuang Gong, You-Ling Chen, and Yun-Feng Xiao [Noncontact rotation, levitation, and acceleration of flowing liquid metal wires]( Yahua He, Jianbo Tang, Kourosh Kalantar-Zadeh, Michael D. Dickey, and Xiaolin Wang Biophysics and Computational Biology [Bicarbonate-controlled reduction of oxygen by the QA semiquinone in Photosystem II in membranes]( Andrea Fantuzzi, Friederike Allgöwer, Holly Baker, Gemma McGuire, Wee Kii Teh, Ana P. Gamiz-Hernandez, Ville R. I. Kaila, and A. William Rutherford [High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS]( Sourav Maity, Gianluca Trinco, Pedro Buzón, Zaid R. Anshari, Noriyuki Kodera, Kien Xuan Ngo, Toshio Ando, Dirk J. Slotboom, and Wouter H. Roos Chemistry [Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca2+-ligated calmodulin]( Thomas Schmidt, Jaekyun Jeon, Wai-Ming Yau, Charles D. Schwieters, Robert Tycko, and G. Marius Clore [Twisted molecular wires polarize spin currents at room temperature]( Chih-Hung Ko, Qirong Zhu, Francesco Tassinari, George Bullard, Peng Zhang, David N. Beratan, Ron Naaman, and Michael J. Therien [A complete description of thermodynamic stabilities of molecular crystals]( Venkat Kapil and Edgar A. Engel [A nitroaromatic cathode with an ultrahigh energy density based on six-electron reaction per nitro group for lithium batteries]( Zifeng Chen, Hai Su, Pengfei Sun, Panxing Bai, Jixing Yang, Mengjie Li, Yunfeng Deng, Yang Liu, Yanhou Geng, and Yunhua Xu [A polarization scheme that resolves cross-peaks with transient absorption and eliminates diagonal peaks in 2D spectroscopy]( Kieran M. Farrell, Nan Yang, and Martin T. Zanni Earth, Atmospheric, and Planetary Sciences [Trends in surface equivalent potential temperature: A more comprehensive metric for global warming and weather extremes]( Fengfei Song, Guang J. Zhang, V. Ramanathan, and L. Ruby Leung [Strong evidence for a weakly oxygenated ocean–atmosphere system during the Proterozoic]( Changle Wang, Maxwell A. Lechte, Christopher T. Reinhard, Dan Asael, Devon B. Cole, Galen P. Halverson, Susannah M. Porter, Nir Galili, Itay Halevy, Robert H. Rainbird, Timothy W. Lyons, and Noah J. Planavsky [Catalytic role of formaldehyde in particulate matter formation]( Eleni Dovrou, Kelvin H. Bates, Jonathan M. Moch, Loretta J. Mickley, Daniel J. Jacob, and Frank N. Keutsch Engineering [In vivo imaging of nanoparticle-labeled CAR T cells]( Louise Kiru, Aimen Zlitni, Aidan Michael Tousley, Guillermo Nicolás Dalton, Wei Wu, Famyrah Lafortune, Anna Liu, Kristen May Cunanan, Hossein Nejadnik, Todd Sulchek, Michael Eugene Moseley, Robbie G. Majzner, and Heike Elisabeth Daldrup-Link Environmental Sciences [High-ammonia selective metal–organic framework–derived Co-doped Fe/Fe2O3 catalysts for electrochemical nitrate reduction]( Shuo Zhang, Miao Li, Jiacheng Li, Qinan Song, and Xiang Liu Physics [Empirical social triad statistics can be explained with dyadic homophylic interactions]( Tuan Minh Pham, Jan Korbel, Rudolf Hanel, and Stefan Thurner [Light emission by free electrons in photonic time-crystals]( Alex Dikopoltsev, Yonatan Sharabi, Mark Lyubarov, Yaakov Lumer, Shai Tsesses, Eran Lustig, Ido Kaminer, and Mordechai Segev [Shape multistability in flexible tubular crystals through interactions of mobile dislocations]( Andrei Zakharov and Daniel A. Beller [Single-domain Bose condensate magnetometer achieves energy resolution per bandwidth below ℏ]( Silvana Palacios Alvarez, Pau Gomez, Simon Coop, Roberto Zamora-Zamora, Chiara Mazzinghi, and Morgan W. Mitchell --------------------------------------------------------------- Social Sciences Anthropology [Spiritual over physical formidability determines willingness to fight and sacrifice through loyalty in cross-cultural populations]( Chad C. Tossell, Angel Gómez, Ewart J. de Visser, Alexandra Vázquez, Bianca T. Donadio, Amanda Metcalfe, Charles Rogan, Richard Davis, and Scott Atran Economic Sciences [High-value decisions are fast and accurate, inconsistent with diminishing value sensitivity]( Blair R. K. Shevlin, Stephanie M. Smith, Jan Hausfeld, and Ian Krajbich [A 680,000-person megastudy of nudges to encourage vaccination in pharmacies]( Katherine L. Milkman, Linnea Gandhi, Mitesh S. Patel, Heather N. Graci, Dena M. Gromet, Hung Ho, Joseph S. Kay, Timothy W. Lee, Jake Rothschild, Jonathan E. Bogard, Ilana Brody, Christopher F. Chabris, Edward Chang, Gretchen B. Chapman, Jennifer E. Dannals, Noah J. Goldstein, Amir Goren, Hal Hershfield, Alex Hirsch, Jillian Hmurovic, Samantha Horn, Dean S. Karlan, Ariella S. Kristal, Cait Lamberton, Michelle N. Meyer, Allison H. Oakes, Maurice E. Schweitzer, Maheen Shermohammed, Joachim Talloen, Caleb Warren, Ashley Whillans, Kuldeep N. Yadav, Julian J. Zlatev, Ron Berman, Chalanda N. Evans, Rahul Ladhania, Jens Ludwig, Nina Mazar, Sendhil Mullainathan, Christopher K. Snider, Jann Spiess, Eli Tsukayama, Lyle Ungar, Christophe Van den Bulte, Kevin G. Volpp, and Angela L. Duckworth [Preferences predict who commits crime among young men]( Thomas Epper, Ernst Fehr, Kristoffer Balle Hvidberg, Claus Thustrup Kreiner, Søren Leth-Petersen, and Gregers Nytoft Rasmussen Environmental Sciences [Early life lead exposure from private well water increases juvenile delinquency risk among US teens]( Jacqueline MacDonald Gibson, John M. MacDonald, Michael Fisher, Xiwei Chen, Aralia Pawlick, and Philip J. Cook Psychological and Cognitive Sciences [Decoding the information structure underlying the neural representation of concepts]( Leonardo Fernandino, Jia-Qing Tong, Lisa L. Conant, Colin J. Humphries, and Jeffrey R. Binder [Comparing the reliability and predictive power of child, teacher, and guardian reports of noncognitive skills]( Shuaizhang Feng, Yujie Han, James J. Heckman, and Tim Kautz Social Sciences [Empirical social triad statistics can be explained with dyadic homophylic interactions]( Tuan Minh Pham, Jan Korbel, Rudolf Hanel, and Stefan Thurner [Pragmatic bias impedes women’s access to political leadership]( Christianne Corbett, Jan G. Voelkel, Marianne Cooper, and Robb Willer --------------------------------------------------------------- Biological Sciences Agricultural Sciences [Variation of TNF modulates cellular immunity of gregarious and solitary locusts against fungal pathogen Metarhizium anisopliae]( Yundan Wang, Xiwen Tong, Shenglei Yuan, Pengcheng Yang, Ling Li, Yong Zhao, and Le Kang Applied Biological Sciences [Single-molecule optofluidic microsensor with interface whispering gallery modes]( Xiao-Chong Yu, Shui-Jing Tang, Wenjing Liu, Yinglun Xu, Qihuang Gong, You-Ling Chen, and Yun-Feng Xiao Biochemistry [DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor]( Raphael I. Benhamou, Blessy M. Suresh, Yuquan Tong, Wesley G. Cochrane, Valerie Cavett, Simon Vezina-Dawod, Daniel Abegg, Jessica L. Childs-Disney, Alexander Adibekian, Brian M. Paegel, and Matthew D. Disney [Bicarbonate-controlled reduction of oxygen by the QA semiquinone in Photosystem II in membranes]( Andrea Fantuzzi, Friederike Allgöwer, Holly Baker, Gemma McGuire, Wee Kii Teh, Ana P. Gamiz-Hernandez, Ville R. I. Kaila, and A. William Rutherford [Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability]( Charlotte Hodson, Jason K. K. Low, Sylvie van Twest, Samuel E. Jones, Paolo Swuec, Vincent Murphy, Kaima Tsukada, Matthew Fawkes, Rohan Bythell-Douglas, Adelina Davies, Jessica K. Holien, Julienne J. O’Rourke, Benjamin L. Parker, Astrid Glaser, Michael W. Parker, Joel P. Mackay, Andrew N. Blackford, Alessandro Costa, and Andrew J. Deans [Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation]( Björn U. Klink, Eric Herrmann, Claudia Antoni, Lars Langemeyer, Stephan Kiontke, Christos Gatsogiannis, Christian Ungermann, Stefan Raunser, and Daniel Kümmel [A distinct RNA recognition mechanism governs Np4 decapping by RppH]( Rose Levenson-Palmer, Daniel J. Luciano, Nikita Vasilyev, Ashok Nuthanakanti, Alexander Serganov, and Joel G. Belasco [BRD4-directed super-enhancer organization of transcription repression programs links to chemotherapeutic efficacy in breast cancer]( Beibei Liu, Xinhua Liu, Lulu Han, Xing Chen, Xiaodi Wu, Jiajing Wu, Dong Yan, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, and Yongfeng Shang Biophysics and Computational Biology [High-speed atomic force microscopy reveals a three-state elevator mechanism in the citrate transporter CitS]( Sourav Maity, Gianluca Trinco, Pedro Buzón, Zaid R. Anshari, Noriyuki Kodera, Kien Xuan Ngo, Toshio Ando, Dirk J. Slotboom, and Wouter H. Roos [Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca2+-ligated calmodulin]( Thomas Schmidt, Jaekyun Jeon, Wai-Ming Yau, Charles D. Schwieters, Robert Tycko, and G. Marius Clore [Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly]( Tebbe de Vries, William Martelly, Sébastien Campagne, Kevin Sabath, Chris P. Sarnowski, Jason Wong, Alexander Leitner, Stefanie Jonas, Shalini Sharma, and Frédéric H.-T. Allain [Electrostatic influence on IL-1 transport through the GSDMD pore]( Wen Jun Xie, Shiyu Xia, Arieh Warshel, and Hao Wu Cell Biology [The cardiac-enriched microprotein mitolamban regulates mitochondrial respiratory complex assembly and function in mice]( Catherine A. Makarewich, Amir Z. Munir, Svetlana Bezprozvannaya, Aaron M. Gibson, Soo Young Kim, Misty S. Martin-Sandoval, Thomas P. Mathews, Luke I. Szweda, Rhonda Bassel-Duby, and Eric N. Olson [iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance]( Shanliang Zheng, Dong Zhao, Guixue Hou, Song Zhao, Wenxin Zhang, Xingwen Wang, Li Li, Liang Lin, Tie-Shan Tang, and Ying Hu [ER-phagy requires the assembly of actin at sites of contact between the cortical ER and endocytic pits]( Dongmei Liu, Muriel Mari, Xia Li, Fulvio Reggiori, Susan Ferro-Novick, and Peter Novick [Leucine retention in lysosomes is regulated by starvation]( Urmi Bandyopadhyay, Pavlina Todorova, Natalya N. Pavlova, Yuma Tada, Craig B. Thompson, Lydia W.S. Finley, and Michael Overholtzer [Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells]( Arin B. Aurora, Vishal Khivansara, Ashley Leach, Jennifer G. Gill, Misty Martin-Sandoval, Chendong Yang, Stacy Y. Kasitinon, Divya Bezwada, Alpaslan Tasdogan, Wen Gu, Thomas P. Mathews, Zhiyu Zhao, Ralph J. DeBerardinis, and Sean J. Morrison [Cryo-ET of Toxoplasma parasites gives subnanometer insight into tubulin-based structures]( Stella Y. Sun, Li-av Segev-Zarko, Muyuan Chen, Grigore D. Pintilie, Michael F. Schmid, Steven J. Ludtke, John C. Boothroyd, and Wah Chiu Developmental Biology [The Yun/Prohibitin complex regulates adult Drosophila intestinal stem cell proliferation through the transcription factor E2F1]( Hang Zhao, Lin Shi, Zhengran Li, Ruiyan Kong, Xuejing Ren, Rui Ma, Lemei Jia, Meifang Ma, Shan Lu, Ran Xu, Richard Binari, Jian-Hua Wang, Meng-qiu Dong, Norbert Perrimon, and Zhouhua Li Ecology [The number of tree species on Earth]( Roberto Cazzolla Gatti, Peter B. Reich, Javier G. P. Gamarra, Tom Crowther, Cang Hui, Albert Morera, Jean-Francois Bastin, Sergio de-Miguel, Gert-Jan Nabuurs, Jens-Christian Svenning, Josep M. Serra-Diaz, Cory Merow, Brian Enquist, Maria Kamenetsky, Junho Lee, Jun Zhu, Jinyun Fang, Douglass F. Jacobs, Bryan Pijanowski, Arindam Banerjee, Robert A. Giaquinto, Giorgio Alberti, Angelica Maria Almeyda Zambrano, Esteban Alvarez-Davila, Alejandro Araujo-Murakami, Valerio Avitabile, Gerardo A. Aymard, Radomir Balazy, Chris Baraloto, Jorcely G. Barroso, Meredith L. Bastian, Philippe Birnbaum, Robert Bitariho, Jan Bogaert, Frans Bongers, Olivier Bouriaud, Pedro H. S. Brancalion, Francis Q. Brearley, Eben North Broadbent, Filippo Bussotti, Wendeson Castro da Silva, Ricardo Gomes César, Goran Češljar, Víctor Chama Moscoso, Han Y. H. Chen, Emil Cienciala, Connie J. Clark, David A. Coomes, Selvadurai Dayanand an, Mathieu Decuyper, Laura E. Dee, Jhon Del Aguila Pasquel, Géraldine Derroire, Marie Noel Kamdem Djuikouo, Tran Van Do, Jiri Dolezal, Ilija Đ. Đorđević, Julien Engel, Tom M. Fayle, Ted R. Feldpausch, Jonas K. Fridman, David J. Harris, Andreas Hemp, Geerten Hengeveld, Bruno Herault, Martin Herold, Thomas Ibanez, Andrzej M. Jagodzinski, Bogdan Jaroszewicz, Kathryn J. Jeffery, Vivian Kvist Johannsen, Tommaso Jucker, Ahto Kangur, Victor N. Karminov, Kuswata Kartawinata, Deborah K. Kennard, Sebastian Kepfer-Rojas, Gunnar Keppel, Mohammed Latif Khan, Pramod Kumar Khare, Timothy J. Kileen, Hyun Seok Kim, Henn Korjus, Amit Kumar, Ashwani Kumar, Diana Laarmann, Nicolas Labrière, Mait Lang, Simon L. Lewis, Natalia Lukina, Brian S. Maitner, Yadvinder Malhi, Andrew R. Marshall, Olga V. Martynenko, Abel L. Monteagudo Mendoza, Petr V. Ontikov, Edgar Ortiz-Malavasi, Nadir C. Pallqui Camacho, Alain Paquette, Minjee Park, Narayanaswamy Parthasarathy, Pablo Lui s Peri, Pascal Petronelli, Sebastian Pfautsch, Oliver L. Phillips, Nicolas Picard, Daniel Piotto, Lourens Poorter, John R. Poulsen, Hans Pretzsch, Hirma Ramírez-Angulo, Zorayda Restrepo Correa, Mirco Rodeghiero, Rocío Del Pilar Rojas Gonzáles, Samir G. Rolim, Francesco Rovero, Ervan Rutishauser, Purabi Saikia, Christian Salas-Eljatib, Dmitry Schepaschenko, Michael Scherer-Lorenzen, Vladimír Šebeň, Marcos Silveira, Ferry Slik, Bonaventure Sonké, Alexandre F. Souza, Krzysztof Jan Stereńczak, Miroslav Svoboda, Hermann Taedoumg, Nadja Tchebakova, John Terborgh, Elena Tikhonova, Armando Torres-Lezama, Fons van der Plas, Rodolfo Vásquez, Helder Viana, Alexander C. Vibrans, Emilio Vilanova, Vincent A. Vos, Hua-Feng Wang, Bertil Westerlund, Lee J. T. White, Susan K. Wiser, Tomasz Zawiła-Niedźwiecki, Lise Zemagho, Zhi-Xin Zhu, Irié C. Zo-Bi, and Jingjing Liang [Top-down and bottom-up cohesiveness in microbial community coalescence]( Juan Diaz-Colunga, Nanxi Lu, Alicia Sanchez-Gorostiaga, Chang-Yu Chang, Helen S. Cai, Joshua E. Goldford, Mikhail Tikhonov, and Álvaro Sánchez [Transmission potential of human schistosomes can be driven by resource competition among snail intermediate hosts]( David J. Civitello, Teckla Angelo, Karena H. Nguyen, Rachel B. Hartman, Naima C. Starkloff, Moses P. Mahalila, Jenitha Charles, Andres Manrique, Bryan K. Delius, L. M. Bradley, Roger M. Nisbet, Safari Kinung’hi, and Jason R. Rohr Environmental Sciences [Predicted wind and solar energy expansion has minimal overlap with multiple conservation priorities across global regions]( Sebastian Dunnett, Robert A. Holland, Gail Taylor, and Felix Eigenbrod [Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production]( Taylor S. Steele, John K. Brunson, Yukari Maeno, Ryuta Terada, Andrew E. Allen, Mari Yotsu-Yamashita, Jonathan R. Chekan, and Bradley S. Moore Evolution [Tracing the cis-regulatory changes underlying the endometrial control of placental invasion]( Yasir Suhail, Jamie D. Maziarz, Ashkan Novin, Anasuya Dighe, Junaid Afzal, Gunter Wagner, and Kshitiz [Thermodynamics of evolution and the origin of life]( Vitaly Vanchurin, Yuri I. Wolf, Eugene V. Koonin, and Mikhail I. Katsnelson [Toward a theory of evolution as multilevel learning]( Vitaly Vanchurin, Yuri I. Wolf, Mikhail I. Katsnelson, and Eugene V. Koonin Genetics [Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development]( Qin Xu, Chao Wang, Jia-Xin Zhou, Zhi-Mei Xu, Juan Gao, Pengfei Sui, Colum P. Walsh, Hongbin Ji, and Guo-Liang Xu [MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function]( Ian G. Chambers, Praveen Kumar, Jens Lichtenberg, Pengcheng Wang, Jianshi Yu, John D. Phillips, Maureen A. Kane, David Bodine, and Iqbal Hamza [A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy]( Georgios Athanasiadis, Joeri J. Meijsen, Dorte Helenius, Andrew J. Schork, Andrés Ingason, Wesley K. Thompson, Daniel H. Geschwind, Thomas Werge, and Alfonso Buil [A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C]( Huiyan Huang, Jiehong Pan, David R. Spielberg, Neil A. Hanchard, Daryl A. Scott, Lindsay C. Burrage, Hongzheng Dai, David Murdock, Jill A. Rosenfeld, Ariz Mohammad, Tao Huang, Anika G. Lindsey, Hyori Kim, Jian Chen, Avinash Ramu, Stephanie A. Morrison, Zachary D. Dawson, Alex Z. Hu, Eric Tycksen, Gary A. Silverman, Dustin Baldridge, Jennifer A. Wambach, Undiagnosed Diseases Network, Stephen C. Pak, Steven L. Brody, and Tim Schedl Immunology and Inflammation [In vivo imaging of nanoparticle-labeled CAR T cells]( Louise Kiru, Aimen Zlitni, Aidan Michael Tousley, Guillermo Nicolás Dalton, Wei Wu, Famyrah Lafortune, Anna Liu, Kristen May Cunanan, Hossein Nejadnik, Todd Sulchek, Michael Eugene Moseley, Robbie G. Majzner, and Heike Elisabeth Daldrup-Link [Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state]( Farzaneh Ghazavi, Jelle Huysentruyt, Jordy De Coninck, Stephanie Kourula, Sofie Martens, Behrouz Hassannia, Tim Wartewig, Tatyana Divert, Ria Roelandt, Bastian Popper, Andreas Hiergeist, Peter Tougaard, Tom Vanden Berghe, Marie Joossens, Geert Berx, Nozomi Takahashi, Adam Wahida, and Peter Vandenabeele [Autoreactive antibodies control blood glucose by regulating insulin homeostasis]( Timm Amendt, Gabriele Allies, Antonella Nicolò, Omar El Ayoubi, Marc Young, Tamás Röszer, Corinna S. Setz, Klaus Warnatz, and Hassan Jumaa [Convergent clonal selection of donor- and recipient-derived CMV-specific T cells in hematopoietic stem cell transplant patients]( Jami R. Erickson, Terry Stevens-Ayers, Florian Mair, Bradley Edmison, Michael Boeckh, Philip Bradley, and Martin Prlic [IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines]( Na-Young Song, Xin Li, Buyong Ma, Jami Willette-Brown, Feng Zhu, Chengfei Jiang, Ling Su, Jyoti Shetty, Yongmei Zhao, Gongping Shi, Sayantan Banerjee, Xiaolin Wu, Bao Tran, Ruth Nussinov, Michael Karin, and Yinling Hu Medical Sciences [A 680,000-person megastudy of nudges to encourage vaccination in pharmacies]( Katherine L. Milkman, Linnea Gandhi, Mitesh S. Patel, Heather N. Graci, Dena M. Gromet, Hung Ho, Joseph S. Kay, Timothy W. Lee, Jake Rothschild, Jonathan E. Bogard, Ilana Brody, Christopher F. Chabris, Edward Chang, Gretchen B. Chapman, Jennifer E. Dannals, Noah J. Goldstein, Amir Goren, Hal Hershfield, Alex Hirsch, Jillian Hmurovic, Samantha Horn, Dean S. Karlan, Ariella S. Kristal, Cait Lamberton, Michelle N. Meyer, Allison H. Oakes, Maurice E. Schweitzer, Maheen Shermohammed, Joachim Talloen, Caleb Warren, Ashley Whillans, Kuldeep N. Yadav, Julian J. Zlatev, Ron Berman, Chalanda N. Evans, Rahul Ladhania, Jens Ludwig, Nina Mazar, Sendhil Mullainathan, Christopher K. Snider, Jann Spiess, Eli Tsukayama, Lyle Ungar, Christophe Van den Bulte, Kevin G. Volpp, and Angela L. Duckworth [miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression]( Chengxin Ma, Dasa He, Pu Tian, Yuan Wang, Yunfei He, Qiuyao Wu, Zhenchang Jia, Xue Zhang, Peiyuan Zhang, Hao Ying, Zi-Bing Jin, and Guohong Hu [Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy]( Jennifer A. White, Francesco R. Simonetti, Subul Beg, Natalie F. McMyn, Weiwei Dai, Niklas Bachmann, Jun Lai, William C. Ford, Christina Bunch, Joyce L. Jones, Ruy. M. Ribeiro, Alan S. Perelson, Janet D. Siliciano, and Robert F. Siliciano [Immunogenicity of rVSVΔG-ZEBOV-GP Ebola vaccination in exposed and potentially exposed persons in the Democratic Republic of the Congo]( Nicole A. Hoff, Anna Bratcher, J. Daniel Kelly, Kamy Musene, Jean Paul Kompany, Michel Kabamba, Placide Mbala-Kingebeni, Bonnie Dighero-Kemp, Gregory Kocher, Elizabeth Elliott, Cavan Reilly, Megan Halbrook, Benoit Ilunga Kebela, Adva Gadoth, Guillaume Ngoie Mwamba, Merly Tambu, David R. McIlwain, Patrick Mukadi, Lisa E. Hensley, Steve Ahuka-Mundeke, George W. Rutherford, Jean Jacques Muyembe-Tamfum, and Anne W. Rimoin [Epigenetic state determines inflammatory sensing in neuroblastoma]( Adam J. Wolpaw, Liron D. Grossmann, Jessica L. Dessau, May M. Dong, Bailey J. Aaron, Patricia A. Brafford, Darya Volgina, Guillem Pascual-Pasto, Alba Rodriguez-Garcia, Yasin Uzun, Marie Arsenian-Henriksson, Daniel J. Powell Jr., Kristopher R. Bosse, Andrew Kossenkov, Kai Tan, Michael D. Hogarty, John M. Maris, and Chi V. Dang [Poly-2-methyl-2-oxazoline–modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration]( Andrey Zakharchenko, Yingfei Xue, Samuel Keeney, Christopher A. Rock, Ivan S. Alferiev, Stanley J. Stachelek, Hajime Takano, Tina Thomas, Chandrasekaran Nagaswami, Abba M. Krieger, Michael Chorny, Giovanni Ferrari, and Robert J. Levy Microbiology [Signaling events that occur when cells of Escherichia coli encounter a glass surface]( Alina M. Vrabioiu and Howard C. Berg [A protease-mediated switch regulates the growth of magnetosome organelles in Magnetospirillum magneticum]( Juan Wan, Patrick J. Browne, David M. Hershey, Elizabeth Montabana, Anthony T. Iavarone, Kenneth H. Downing, and Arash Komeili [Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein]( Yunlong Shi, Ari Zeida, Caitlin E. Edwards, Michael L. Mallory, Santiago Sastre, Matías R. Machado, Raymond J. Pickles, Ling Fu, Keke Liu, Jing Yang, Ralph S. Baric, Richard C. Boucher, Rafael Radi, and Kate S. Carroll [Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer]( Suresh V. Kuchipudi, Meera Surendran-Nair, Rachel M. Ruden, Michele Yon, Ruth H. Nissly, Kurt J. Vandegrift, Rahul K. Nelli, Lingling Li, Bhushan M. Jayarao, Costas D. Maranas, Nicole Levine, Katriina Willgert, Andrew J. K. Conlan, Randall J. Olsen, James J. Davis, James M. Musser, Peter J. Hudson, and Vivek Kapur [Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells]( Razie Amraei, Chaoshuang Xia, Judith Olejnik, Mitchell R. White, Marc A. Napoleon, Saran Lotfollahzadeh, Blake M. Hauser, Aaron G. Schmidt, Vipul Chitalia, Elke Mühlberger, Catherine E. Costello, and Nader Rahimi [Conformation and dynamic interactions of the multipartite genome in Agrobacterium tumefaciens]( Zhongqing Ren, Qin Liao, Xheni Karaboja, Ian S. Barton, Eli G. Schantz, Adrian Mejia-Santana, Clay Fuqua, and Xindan Wang [A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains]( Tatsuaki Kurata, Chayan Kumar Saha, Jessica A. Buttress, Toomas Mets, Tetiana Brodiazhenko, Kathryn J. Turnbull, Ololade F. Awoyomi, Sofia Raquel Alves Oliveira, Steffi Jimmy, Karin Ernits, Maxence Delannoy, Karina Persson, Tanel Tenson, Henrik Strahl, Vasili Hauryliuk, and Gemma C. Atkinson [Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions]( Fin J. Milder, Mandy Jongeneelen, Tina Ritschel, Pascale Bouchier, Ilona J. M. Bisschop, Martijn de Man, Daniel Veldman, Lam Le, Baerbel Kaufmann, Mark J. G. Bakkers, Jarek Juraszek, Boerries Brandenburg, and Johannes P. M. Langedijk [Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex]( Katie Nightingale, Martin Potts, Leah M. Hunter, Ceri A. Fielding, Cassie M. Zerbe, Alice Fletcher-Etherington, Luis Nobre, Eddie C. Y. Wang, Blair L. Strang, Jack W. Houghton, Robin Antrobus, Nicolas M. Suarez, Jenna Nichols, Andrew J. Davison, Richard J. Stanton, and Michael P. Weekes [Impact of ADAR-induced editing of minor viral RNA populations on replication and transmission of SARS-CoV-2]( Johan Ringlander, Joshua Fingal, Hanna Kann, Kasthuri Prakash, Gustaf Rydell, Maria Andersson, Anna Martner, Magnus Lindh, Peter Horal, Kristoffer Hellstrand, and Michael Kann [A noncanonical cytochrome c stimulates calcium binding by PilY1 for type IVa pili formation]( Marco Herfurth, Anke Treuner-Lange, Timo Glatter, Nadine Wittmaack, Egbert Hoiczyk, Antonio J. Pierik, and Lotte Søgaard-Andersen Neuroscience [Decoding the information structure underlying the neural representation of concepts]( Leonardo Fernandino, Jia-Qing Tong, Lisa L. Conant, Colin J. Humphries, and Jeffrey R. Binder [Hierarchical timescales in the neocortex: Mathematical mechanism and biological insights]( Songting Li and Xiao-Jing Wang [Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy]( Jacob I. Ayers, Joanne Lee, Octovia Monteiro, Amanda L. Woerman, Ann A. Lazar, Carlo Condello, Nick A. Paras, and Stanley B. 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Smith, Jan Hausfeld, and Ian Krajbich Systems Biology [In vitro cell cycle oscillations exhibit a robust and hysteretic response to changes in cytoplasmic density]( Minjun Jin, Franco Tavella, Shiyuan Wang, and Qiong Yang [Engineering and functional analysis of yeast with a monotypic 40S ribosome subunit]( Xin Hu, Shuangying Jiang, Feifei Xu, Cheng Zeng, Xiangxiang Wang, Wei Liu, Aimin Cheng, Chengying Ma, Ning Gao, Yuyu Zhao, Junbiao Dai, and Guanghou Zhao --------------------------------------------------------------- Corrections [Correction for Manski et al., Addressing partial identification in climate modeling and policy analysis]( [Correction for Williams et al., Chromosome 10q26–driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium]( --------------------------------------------------------------- Editorial Expression of Concern [Editorial Expression of Concern: Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo]( [Cover] --------------------------------------------------------------- This message was sent to {EMAIL}. 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