[PNAS][Proceedings of the National Academy of Sciences]
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[Proceedings of the National Academy of Sciences](?etoc) [21 February 2017; Vol. 114, No. 8](
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This Week in PNAS
[In This Issue](
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Letters (Online Only)
[Are human heads getting larger?](
Richard Grossman
[Reply to Grossman: The role of natural selection for the increase of Caesarean section rates](
Philipp Mitteroecker, Simon M. Huttegger, Barbara Fischer, and Mihaela Pavlicev
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Opinion
[Opinion: Gender diversity leads to better science]( [Front Matter Article]
Mathias Wullum Nielsen, Sharla Alegria, Love Börjeson, Henry Etzkowitz, Holly J. Falk-Krzesinski, Aparna Joshi, Erin Leahey, Laurel Smith-Doerr, Anita Williams Woolley, and Londa Schiebinger
Leading scientists discuss current issues.
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Retrospective
[Ahmed Zewail: A force for Egyptian science](
Mostafa A. El-Sayed
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Profiles
[Profile of David Heeger](
Brian Doctrow
[Profile of Lily and Yuh Nung Jan, winners of the 2017 Vilcek Prize in Biomedical Science](
Prashant Nair and Jan Vilcek
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Commentaries
[Losing pieces without disintegrating: Contractile protein loss during muscle atrophy](
Stefano Schiaffino
[Myosin-driven transport network in plants is functionally robust and distinctive](
Vitaly Citovsky and Bo Liu
[Getting to the bottom of global fishery catches](
Éva Elizabeth Plagányi
[Targeting tail-anchored proteins into plant organelles](
Xiaohong Zhuang, Kin Pan Chung, and Liwen Jiang
[Deconstructing mammalian thermoregulation](
Wolfgang B. Liedtke
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PNAS Plus Significance Statements
[PNAS Plus Significance Statements](
Brief statements written by the authors about the significance of their papers.
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Physical Sciences
Applied Physical Sciences
[Pure circular polarization electroluminescence at room temperature with spin-polarized light-emitting diodes](
Nozomi Nishizawa, Kazuhiro Nishibayashi, and Hiro Munekata
Chemistry
[High-resolution imaging of cellular dopamine efflux using a fluorescent nanosensor array](
Sebastian Kruss, Daniel P. Salem, Lela Vuković, Barbara Lima, Emma Vander Ende, Edward S. Boyden, and Michael S. Strano
[Full atomistic reaction mechanism with kinetics for CO reduction on Cu(100) from ab initio molecular dynamics free-energy calculations at 298 K](
Tao Cheng, Hai Xiao, and William A. Goddard III
[Probing equilibrium of molecular and deprotonated water on TiO2(110)](
Zhi-Tao Wang, Yang-Gang Wang, Rentao Mu, Yeohoon Yoon, Arjun Dahal, Gregory K. Schenter, Vassiliki-Alexandra Glezakou, Roger Rousseau, Igor Lyubinetsky, and Zdenek Dohnálek
Earth, Atmospheric, and Planetary Sciences
[Redox chemistry changes in the Panthalassic Ocean linked to the end-Permian mass extinction and delayed Early Triassic biotic recovery]( [Open Access Article]
Guijie Zhang, Xiaolin Zhang, Dongping Hu, Dandan Li, Thomas J. Algeo, James Farquhar, Charles M. Henderson, Liping Qin, Megan Shen, Danielle Shen, Shane D. Schoepfer, Kefan Chen, and Yanan Shen
[Timing and tempo of the Great Oxidation Event]( [Open Access Article]
Ashley P. Gumsley, Kevin R. Chamberlain, Wouter Bleeker, Ulf Söderlund, Michiel O. de Kock, Emilie R. Larsson, and Andrey Bekker
[Northward extent of East Asian monsoon covaries with intensity on orbital and millennial timescales](
Yonaton Goldsmith, Wallace S. Broecker, Hai Xu, Pratigya J. Polissar, Peter B. deMenocal, Naomi Porat, Jianghu Lan, Peng Cheng, Weijian Zhou, and Zhisheng An
[Role of eruption season in reconciling model and proxy responses to tropical volcanism](
Samantha Stevenson, John T. Fasullo, Bette L. Otto-Bliesner, Robert A. Tomas, and Chaochao Gao
[K isotopes as a tracer of seafloor hydrothermal alteration](
Christopher A. Parendo, Stein B. Jacobsen, and Kun Wang
Engineering
[Multifunctional, inexpensive, and reusable nanoparticle-printed biochip for cell manipulation and diagnosis](
Rahim Esfandyarpour, Matthew J. DiDonato, Yuxin Yang, Naside Gozde Durmus, James S. Harris, and Ronald W. Davis
[Architected cellular ceramics with tailored stiffness via direct foam writing](
Joseph T. Muth, Patrick G. Dixon, Logan Woish, Lorna J. Gibson, and Jennifer A. Lewis
[Role of vascular normalization in benefit from metronomic chemotherapy](
Fotios Mpekris, James W. Baish, Triantafyllos Stylianopoulos, and Rakesh K. Jain
[Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics](
James E. Dahlman, Kevin J. Kauffman, Yiping Xing, Taylor E. Shaw, Faryal F. Mir, Chloe C. Dlott, Robert Langer, Daniel G. Anderson, and Eric T. Wang
Physics
[A statics-dynamics equivalence through the fluctuation–dissipation ratio provides a window into the spin-glass phase from nonequilibrium measurements](
Marco Baity-Jesi, Enrico Calore, Andres Cruz, Luis Antonio Fernandez, José Miguel Gil-Narvión, Antonio Gordillo-Guerrero, David Iñiguez, Andrea Maiorano, Enzo Marinari, Victor Martin-Mayor, Jorge Monforte-Garcia, Antonio Muñoz Sudupe, Denis Navarro, Giorgio Parisi, Sergio Perez-Gaviro, Federico Ricci-Tersenghi, Juan Jesus Ruiz-Lorenzo, Sebastiano Fabio Schifano, Beatriz Seoane, Alfonso Tarancón, Raffaele Tripiccione, and David Yllanes
[Quantum chaos on a critical Fermi surface](
Aavishkar A. Patel and Subir Sachdev
[Long-wavelength fluctuations and the glass transition in two dimensions and three dimensions]( [From the Cover]
Skanda Vivek, Colm P. Kelleher, Paul M. Chaikin, and Eric R. Weeks
[Mermin–Wagner fluctuations in 2D amorphous solids]( [Open Access Article] [From the Cover]
Bernd Illing, Sebastian Fritschi, Herbert Kaiser, Christian L. Klix, Georg Maret, and Peter Keim
Sustainability Science
[Reconciling fisheries catch and ocean productivity](
Charles A. Stock, Jasmin G. John, Ryan R. Rykaczewski, Rebecca G. Asch, William W. L. Cheung, John P. Dunne, Kevin D. Friedland, Vicky W. Y. Lam, Jorge L. Sarmiento, and Reg A. Watson
[Spatially resolved air-water emissions tradeoffs improve regulatory impact analyses for electricity generation](
Daniel B. Gingerich, Xiaodi Sun, A. Patrick Behrer, Inês L. Azevedo, and Meagan S. Mauter
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Social Sciences
Environmental Sciences
[Impact of pre-Columbian “geoglyph” builders on Amazonian forests](
Jennifer Watling, José Iriarte, Francis E. Mayle, Denise Schaan, Luiz C. R. Pessenda, Neil J. Loader, F. Alayne Street-Perrott, Ruth E. Dickau, Antonia Damasceno, and Alceu Ranzi
Psychological and Cognitive Sciences
[Theory of cortical function]( [Inaugural Article]
David J. Heeger
[Cross-cultural regularities in the cognitive architecture of pride](
Daniel Sznycer, Laith Al-Shawaf, Yoella Bereby-Meyer, Oliver Scott Curry, Delphine De Smet, Elsa Ermer, Sangin Kim, Sunhwa Kim, Norman P. Li, Maria Florencia Lopez Seal, Jennifer McClung, Jiaqing O, Yohsuke Ohtsubo, Tadeg Quillien, Max Schaub, Aaron Sell, Florian van Leeuwen, Leda Cosmides, and John Tooby
[Distributed representation of context by intrinsic subnetworks in prefrontal cortex](
Michael L. Waskom and Anthony D. Wagner
Sustainability Science
[Impact of pre-Columbian “geoglyph” builders on Amazonian forests](
Jennifer Watling, José Iriarte, Francis E. Mayle, Denise Schaan, Luiz C. R. Pessenda, Neil J. Loader, F. Alayne Street-Perrott, Ruth E. Dickau, Antonia Damasceno, and Alceu Ranzi
[Global socioeconomic material stocks rise 23-fold over the 20th century and require half of annual resource use]( [Open Access Article]
Fridolin Krausmann, Dominik Wiedenhofer, Christian Lauk, Willi Haas, Hiroki Tanikawa, Tomer Fishman, Alessio Miatto, Heinz Schandl, and Helmut Haberl
[Climate change is projected to have severe impacts on the frequency and intensity of peak electricity demand across the United States]( [Open Access Article]
Maximilian Auffhammer, Patrick Baylis, and Catherine H. Hausman
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Biological Sciences
Anthropology
[Female sociality and sexual conflict shape offspring survival in a Neotropical primate](
Urs Kalbitzer, Mackenzie L. Bergstrom, Sarah D. Carnegie, Eva C. Wikberg, Shoji Kawamura, Fernando A. Campos, Katharine M. Jack, and Linda M. Fedigan
Applied Biological Sciences
[Multifunctional, inexpensive, and reusable nanoparticle-printed biochip for cell manipulation and diagnosis](
Rahim Esfandyarpour, Matthew J. DiDonato, Yuxin Yang, Naside Gozde Durmus, James S. Harris, and Ronald W. Davis
[Estrogen receptor α wields treatment-specific enhancers between morphologically similar endometrial tumors](
Marjolein Droog, Ekaterina Nevedomskaya, Gwen M. Dackus, Renske Fles, Yongsoo Kim, Harry Hollema, Marian Mourits, Petra M. Nederlof, Hester H. van Boven, Sabine C. Linn, Flora E. van Leeuwen, Lodewyk F. A. Wessels, and Wilbert Zwart
[Modular assembly of thick multifunctional cardiac patches]( [Open Access Article]
Sharon Fleischer, Assaf Shapira, Ron Feiner, and Tal Dvir
Biochemistry
[Kinetics, subcellular localization, and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP)](
Martín Hugo, Alejandra Martínez, Madia Trujillo, Damián Estrada, Mauricio Mastrogiovanni, Edlaine Linares, Ohara Augusto, Federico Issoglio, Ari Zeida, Darío A. Estrín, Harry F. G. Heijnen, Lucía Piacenza, and Rafael Radi
[H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinase]( [Open Access Article]
John Bettridge, Chan Hyun Na, Akhilesh Pandey, and Stephen Desiderio
[Biosynthesis of cabbage phytoalexins from indole glucosinolate](
Andrew P. Klein and Elizabeth S. Sattely
Biophysics and Computational Biology
[Reaction dynamics analysis of a reconstituted Escherichia coli protein translation system by computational modeling]( [Open Access Article]
Tomoaki Matsuura, Naoki Tanimura, Kazufumi Hosoda, Tetsuya Yomo, and Yoshihiro Shimizu
[Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant](
Holly E. Dembinski, Kevin Wismer, Jesse D. Vargas, Gajendra W. Suryawanshi, Nadja Kern, Gerard Kroon, H. Jane Dyson, Alexander Hoffmann, and Elizabeth A. Komives
[Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection](
Yoshiki Koizumi, Hirofumi Ohashi, Syo Nakajima, Yasuhito Tanaka, Takaji Wakita, Alan S. Perelson, Shingo Iwami, and Koichi Watashi
Cell Biology
[Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling](
Myong-Ho Jeong, Hyun-Ji Kim, Jung-Hoon Pyun, Kyu-Sil Choi, Dong I. Lee, Soroosh Solhjoo, Brian O'Rourke, Gordon F. Tomaselli, Dong Seop Jeong, Hana Cho, and Jong-Sun Kang
[Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments]( [Open Access Article]
Robert W. Kensler, Roger Craig, and Richard L. Moss
[Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry]( [Open Access Article]
Jennifer Greaves, Kevin R. Munro, Stuart C. Davidson, Matthieu Riviere, Justyna Wojno, Terry K. Smith, Nicholas C. O. Tomkinson, and Luke H. Chamberlain
[Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization](
Alexandra Volodin, Idit Kosti, Alfred Lewis Goldberg, and Shenhav Cohen
[Myosin-driven transport network in plants]( [Open Access Article]
Elizabeth G. Kurth, Valera V. Peremyslov, Hannah L. Turner, Kira S. Makarova, Jaime Iranzo, Sergei L. Mekhedov, Eugene V. Koonin, and Valerian V. Dolja
[Targeting IRE1 with small molecules counteracts progression of atherosclerosis]( [Open Access Article]
Ozlem Tufanli, Pelin Telkoparan Akillilar, Diego Acosta-Alvear, Begum Kocaturk, Umut Inci Onat, Syed Muhammad Hamid, Ismail Çimen, Peter Walter, Christian Weber, and Ebru Erbay
[An amidase is required for proper intercellular communication in the filamentous cyanobacterium Anabaena sp. PCC 7120](
Zhenggao Zheng, Amin Omairi-Nasser, Xiying Li, Chunxia Dong, Yan Lin, Robert Haselkorn, and Jindong Zhao
[RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo]( [Open Access Article]
Twana Alkasalias, Andrey Alexeyenko, Katharina Hennig, Frida Danielsson, Robert Jan Lebbink, Matthew Fielden, S. Pauliina Turunen, Kaisa Lehti, Vladimir Kashuba, Harsha S. Madapura, Benedek Bozoky, Emma Lundberg, Martial Balland, Hayrettin Guvén, George Klein, Annica K. B. Gad, and Tatiana Pavlova
[Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T]( [Open Access Article]
Simona Giunta and Hironori Funabiki
Developmental Biology
[Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation](
Lun Zhou, Jielin Liu, Menglan Xiang, Patrick Olson, Alexander Guzzetta, Ke Zhang, Ivan P. Moskowitz, and Linglin Xie
[Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia](
Shujuan Chen, Wenqi Lu, Mei-Fei Yueh, Eva Rettenmeier, Miao Liu, Johan Auwerx, Ruth T. Yu, Ronald M. Evans, Kepeng Wang, Michael Karin, and Robert H. Tukey
[Hippo signaling promotes JNK-dependent cell migration](
Xianjue Ma, Hongxiang Wang, Jiansong Ji, Wenyan Xu, Yihao Sun, Wenzhe Li, Xiaoping Zhang, Juxiang Chen, and Lei Xue
[Up-regulation of CD81 inhibits cytotrophoblast invasion and mediates maternal endothelial cell dysfunction in preeclampsia]( [Open Access Article]
Li Shen, Zhenyu Diao, Hai-Xiang Sun, Gui-Jun Yan, Zhiqun Wang, Ruo-Tian Li, Yimin Dai, Jingmei Wang, Jie Li, Hailing Ding, Guangfeng Zhao, Mingming Zheng, Pingping Xue, Mo Liu, Yan Zhou, and Yali Hu
Ecology
[Reconciling fisheries catch and ocean productivity](
Charles A. Stock, Jasmin G. John, Ryan R. Rykaczewski, Rebecca G. Asch, William W. L. Cheung, John P. Dunne, Kevin D. Friedland, Vicky W. Y. Lam, Jorge L. Sarmiento, and Reg A. Watson
[Ghrelin affects stopover decisions and food intake in a long-distance migrant]( [Open Access Article]
Wolfgang Goymann, Sara Lupi, Hiroyuki Kaiya, Massimiliano Cardinale, and Leonida Fusani
Environmental Sciences
[Interaction between top-down and bottom-up control in marine food webs]( [Open Access Article]
Christopher Philip Lynam, Marcos Llope, Christian Möllmann, Pierre Helaouët, Georgia Anne Bayliss-Brown, and Nils C. Stenseth
Evolution
[Selection maintains signaling function of a highly diverged intrinsically disordered region](
Taraneh Zarin, Caressa N. Tsai, Alex N. Nguyen Ba, and Alan M. Moses
[Dynamics of genome size evolution in birds and mammals]( [Open Access Article]
Aurélie Kapusta, Alexander Suh, and Cédric Feschotte
[Cross-cultural regularities in the cognitive architecture of pride](
Daniel Sznycer, Laith Al-Shawaf, Yoella Bereby-Meyer, Oliver Scott Curry, Delphine De Smet, Elsa Ermer, Sangin Kim, Sunhwa Kim, Norman P. Li, Maria Florencia Lopez Seal, Jennifer McClung, Jiaqing O, Yohsuke Ohtsubo, Tadeg Quillien, Max Schaub, Aaron Sell, Florian van Leeuwen, Leda Cosmides, and John Tooby
Genetics
[Low escape-rate genome safeguards with minimal molecular perturbation of Saccharomyces cerevisiae](
Neta Agmon, Zuojian Tang, Kun Yang, Ben Sutter, Shigehito Ikushima, Yizhi Cai, Katrina Caravelli, James A. Martin, Xiaoji Sun, Woo Jin Choi, Allen Zhang, Giovanni Stracquadanio, Haiping Hao, Benjamin P. Tu, David Fenyo, Joel S. Bader, and Jef D. Boeke
[Hearing regulates Drosophila aggression](
Marijke Versteven, Lies Vanden Broeck, Bart Geurten, Liesbeth Zwarts, Lisse Decraecker, Melissa Beelen, Martin C. Göpfert, Ralf Heinrich, and Patrick Callaerts
[iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations](
Erika M. Kwon, John P. Connelly, Nancy F. Hansen, Frank X. Donovan, Thomas Winkler, Brian W. Davis, Halah Alkadi, Settara C. Chandrasekharappa, Cynthia E. Dunbar, James C. Mullikin, and Paul Liu
[Failure to reproduce period-dependent song cycles in Drosophila is due to poor automated pulse-detection and low-intensity courtship]( [Open Access Article]
Charalambos P. Kyriacou, Edward W. Green, Arianna Piffer, and Harold B. Dowse
Immunology and Inflammation
[TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity](
Dominika Lukas, Nir Yogev, Junda M. Kel, Tommy Regen, Ilgiz A. Mufazalov, Yilang Tang, Florian Wanke, Boris Reizis, Werner Müller, Florian C. Kurschus, Marco Prinz, Ingo Kleiter, Björn E. Clausen, and Ari Waisman
[Dnmt3a restrains mast cell inflammatory responses](
Cristina Leoni, Sara Montagner, Andrea Rinaldi, Francesco Bertoni, Sara Polletti, Chiara Balestrieri, and Silvia Monticelli
[Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection]( [Open Access Article]
Geetha H. Mylvaganam, Daniel Rios, Hadia M. Abdelaal, Smita Iyer, Gregory Tharp, Maud Mavinger, Sakeenah Hicks, Ann Chahroudi, Rafi Ahmed, Steven E. Bosinger, Ifor R. Williams, Pamela J. Skinner, Vijayakumar Velu, and Rama R. Amara
[Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1](
Gillian L. Dornan, Braden D. Siempelkamp, Meredith L. Jenkins, Oscar Vadas, Carrie L. Lucas, and John E. Burke
[A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes](
Hong Zhang, Josh D. Gregorio, Toru Iwahori, Xiangyue Zhang, Okmi Choi, Lorna L. Tolentino, Tyler Prestwood, Yaron Carmi, and Edgar G. Engleman
Medical Sciences
[SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis](
Yuanzhong Wang, Dujin Zhou, Sheryl Phung, Charles Warden, Rumana Rashid, Nymph Chan, and Shiuan Chen
[Gene activation of SMN by selective disruption of lncRNA-mediated recruitment of PRC2 for the treatment of spinal muscular atrophy]( [Open Access Article]
Caroline J. Woo, Verena K. Maier, Roshni Davey, James Brennan, Guangde Li, John Brothers II, Brian Schwartz, Susana Gordo, Anne Kasper, Trevor R. Okamoto, Hans E. Johansson, Berhan Mandefro, Dhruv Sareen, Peter Bialek, B. Nelson Chau, Balkrishen Bhat, David Bullough, and James Barsoum
[Role of vascular normalization in benefit from metronomic chemotherapy](
Fotios Mpekris, James W. Baish, Triantafyllos Stylianopoulos, and Rakesh K. Jain
[High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS](
Cuiwen He, Xuchen Hu, Rachel S. Jung, Thomas A. Weston, Norma P. Sandoval, Peter Tontonoz, Matthew R. Kilburn, Loren G. Fong, Stephen G. Young, and Haibo Jiang
[Synergistic antileukemic therapies in NOTCH1-induced T-ALL](
Marta Sanchez-Martin, Alberto Ambesi-Impiombato, Yue Qin, Daniel Herranz, Mukesh Bansal, Tiziana Girardi, Elisabeth Paietta, Martin S. Tallman, Jacob M. Rowe, Kim De Keersmaecker, Andrea Califano, and Adolfo A. Ferrando
[Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation](
Veit Rothhammer, Jessica E. Kenison, Emily Tjon, Maisa C. Takenaka, Kalil Alves de Lima, Davis M. Borucki, Chun-Cheih Chao, Annabel Wilz, Manon Blain, Luke Healy, Jack Antel, and Francisco J. Quintana
Microbiology
[Bordetella PlrSR regulatory system controls BvgAS activity and virulence in the lower respiratory tract](
M. Ashley Bone, Aaron J. Wilk, Andrew I. Perault, Sara A. Marlatt, Erich V. Scheller, Rebecca Anthouard, Qing Chen, Scott Stibitz, Peggy A. Cotter, and Steven M. Julio
[ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection](
Anna Vysochan, Arjun Sengupta, Aalim M. Weljie, James C. Alwine, and Yongjun Yu
[Systematic identification of anti-interferon function on hepatitis C virus genome reveals p7 as an immune evasion protein](
Hangfei Qi, Virginia Chu, Nicholas C. Wu, Zugen Chen, Shawna Truong, Gurpreet Brar, Sheng-Yao Su, Yushen Du, Vaithilingaraja Arumugaswami, C. Anders Olson, Shu-Hua Chen, Chung-Yen Lin, Ting-Ting Wu, and Ren Sun
[AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses]( [Open Access Article]
Audrey Stéphanie Richard, Byoung-Shik Shim, Young-Chan Kwon, Rong Zhang, Yuka Otsuka, Kimberly Schmitt, Fatma Berri, Michael S. Diamond, and Hyeryun Choe
Neuroscience
[Theory of cortical function]( [Inaugural Article]
David J. Heeger
[High-resolution imaging of cellular dopamine efflux using a fluorescent nanosensor array](
Sebastian Kruss, Daniel P. Salem, Lela Vuković, Barbara Lima, Emma Vander Ende, Edward S. Boyden, and Michael S. Strano
[Distributed representation of context by intrinsic subnetworks in prefrontal cortex](
Michael L. Waskom and Anthony D. Wagner
[Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase](
Chenglai Fu, Jing Xu, Weiwei Cheng, Tomas Rojas, Alfred C. Chin, Adele M. Snowman, Maged M. Harraz, and Solomon H. Snyder
[A hypothalamic circuit that controls body temperature]( [From the Cover]
Zheng-Dong Zhao, Wen Z. Yang, Cuicui Gao, Xin Fu, Wen Zhang, Qian Zhou, Wanpeng Chen, Xinyan Ni, Jun-Kai Lin, Juan Yang, Xiao-Hong Xu, and Wei L. Shen
[Reelin transiently promotes N-cadherin–dependent neuronal adhesion during mouse cortical development](
Yuki Matsunaga, Mariko Noda, Hideki Murakawa, Kanehiro Hayashi, Arata Nagasaka, Seika Inoue, Takaki Miyata, Takashi Miura, Ken-ichiro Kubo, and Kazunori Nakajima
[Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians]( [Open Access Article]
Matteo Cortese, Samantha Papal, Francisco Pisciottano, Ana Belén Elgoyhen, Jean-Pierre Hardelin, Christine Petit, Lucia Florencia Franchini, and Aziz El-Amraoui
Pharmacology
[Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics](
James E. Dahlman, Kevin J. Kauffman, Yiping Xing, Taylor E. Shaw, Faryal F. Mir, Chloe C. Dlott, Robert Langer, Daniel G. Anderson, and Eric T. Wang
[Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket]( [Open Access Article]
Bingfa Sun, Priti Bachhawat, Matthew Ling-Hon Chu, Martyn Wood, Tom Ceska, Zara A. Sands, Joel Mercier, Florence Lebon, Tong Sun Kobilka, and Brian K. Kobilka
Physiology
[MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases](
Ding-Yu Lee, Ting-Er Lin, Chih-I Lee, Jing Zhou, Yi-Hsuan Huang, Pei-Ling Lee, Yu-Tsung Shih, Shu Chien, and Jeng-Jiann Chiu
Plant Biology
[Proteomic analysis reveals O-GlcNAc modification on proteins with key regulatory functions in Arabidopsis](
Shou-Ling Xu, Robert J. Chalkley, Jason C. Maynard, Wenfei Wang, Weimin Ni, Xiaoyue Jiang, Kihye Shin, Ling Cheng, Dasha Savage, Andreas F. R. Hühmer, Alma L. Burlingame, and Zhi-Yong Wang
[Loss of GET pathway orthologs in Arabidopsis thaliana causes root hair growth defects and affects SNARE abundance]( [Open Access Article]
Shuping Xing, Dietmar Gerald Mehlhorn, Niklas Wallmeroth, Lisa Yasmin Asseck, Ritwika Kar, Alessa Voss, Philipp Denninger, Vanessa Aphaia Fiona Schmidt, Markus Schwarzländer, York-Dieter Stierhof, Guido Grossmann, and Christopher Grefen
[PPR-SMR protein SOT1 has RNA endonuclease activity](
Wen Zhou, Qingtao Lu, Qingwei Li, Lei Wang, Shunhua Ding, Aihong Zhang, Xiaogang Wen, Lixin Zhang, and Congming Lu
[Control of DEMETER DNA demethylase gene transcription in male and female gamete companion cells in Arabidopsis thaliana]( [Open Access Article] [From the Cover]
Jin-Sup Park, Jennifer M. Frost, Kyunghyuk Park, Hyonhwa Ohr, Guen Tae Park, Seohyun Kim, Hyunjoo Eom, Ilha Lee, Janie S. Brooks, Robert L. Fischer, and Yeonhee Choi
[HY5, a positive regulator of light signaling, negatively controls the unfolded protein response in Arabidopsis]( [Open Access Article]
Ganesh M. Nawkar, Chang Ho Kang, Punyakishore Maibam, Joung Hun Park, Young Jun Jung, Ho Byoung Chae, Yong Hun Chi, In Jung Jung, Woe Yeon Kim, Dae-Jin Yun, and Sang Yeol Lee
Psychological and Cognitive Sciences
[Human and rat gut microbiome composition is maintained following sleep restriction](
Shirley L. Zhang, Lei Bai, Namni Goel, Aubrey Bailey, Christopher J. Jang, Frederic D. Bushman, Peter Meerlo, David F. Dinges, and Amita Sehgal
Sustainability Science
[Global socioeconomic material stocks rise 23-fold over the 20th century and require half of annual resource use]( [Open Access Article]
Fridolin Krausmann, Dominik Wiedenhofer, Christian Lauk, Willi Haas, Hiroki Tanikawa, Tomer Fishman, Alessio Miatto, Heinz Schandl, and Helmut Haberl
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Corrections (Online Only)
[Correction for Slovic et al., Iconic photographs and the ebb and flow of empathic response to humanitarian disasters](
[Correction for Holm et al., Arginine substitution of a cysteine in transmembrane helix M8 converts Na+,K+-ATPase to an electroneutral pump similar to H+,K+-ATPase](
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SI Correction (Online Only)
[Correction to Supporting Information for Andreu-Fernández et al., Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes](
[Cover]
Open Access
From the Cover
Inaugural Article
Classic
Cozzarelli Prize Winner
Front Matter ---------------------------------------------------------------
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Copyright © 2017 by the National Academy of Sciences