Rare Disease Tech 🔥

What the fail of KovakDx says about HealthTech incentives.                                                                                                                                                                                                                                                                                                                                                                                                                 [Read Online]( Rare Disease Tech What the fail of KovakDx says about HealthTech incentives. [Nicolás Cerdeira]( [fb]( [tw]( [in]( [email](mailto:?subject=Post%20from%20Failory&body=Rare%20Disease%20Tech%3A%20What%20the%20fail%20of%20KovakDx%20says%20about%20HealthTech%20incentives.%0A%0Ahttps%3A%2F%2Fnewsletter.failory.com%2Fp%2Frare-disease-tech) Hey — It’s Nico. Today’s issue takes 5 minutes to read. If you only have one, here are the five main things: - KovaDx, a HealtTech startup researching a rare disease, [shut down]( (read why below). - One of the OpenAI's co-founders [launched a new company](. - [OpenAI acquires]( remote collaboration startup Multi. - 10-minute delivery app [Zepto raises $665M]( at a $3.6B valuation. - Anthropic released its latest AI model: [Claude 3.5 Sonnet]( (read about it below) This issue is brought to you by [Intercom’s early stage program](, offering a 100% discount to startups. Let’s get into it. Intercom for Startups [Join Intercom’s Early Stage Program]( to receive a 100% discount. Get a direct line to your customers. Try the only complete AI-first customer service solution. [Apply Now →]( This Week In Startups 🔗 Resources YC startup Resend’s [playbook on engineering, design, support, and marketing](. How LaunchDarkly’s CPO created a [six-figure AI product manager as a side hustle](. Evaluating the ROI of [joining an incubator or accelerator](. Maven's founder shares how [they've navigated product-market fit](. [Growth tactics]( from Canva, Figma, ChatGPT, and more. 📰 News IIya Sutskever [launches a new AI company](.   [OpenAI acquires]( remote collaboration startup Multi. [Prosus slashes its $2.1B in Byju’s to zero]( but remains hopeful for recovery. [Zendesk launches VC arm]( to back early-stage AI startups Fintech unicorn [Unit lays off 15%]( of its workforce. 💸 Fundraising 10-minute delivery app [Zepto raises $665M]( at a $3.6B valuation. Accounting Startup [Klarity secures $70M Series B]( to continue building AI capabilities. [Decagon emerges from stealth with $35M]( to provide ‘human-like’ AI agents for enterprises. [Khosla-backed Marble raises $5M]( to offer affordable group therapy for teens. Ex-HubSpot exec [launches AI-powered CRM]( [Day.ai]( and raises $4M. Fail(St)ory Rare Disease Tech KovaDx, a health tech startup focused on helping people with sickle cell disease, announced it is shutting down. Why It Matters: - Sickle Cell Disease (SCD) is one of the most poorly funded diseases. - It is a genetic disorder that primarily affects people of African ancestry. In the US, it affects [1 in 365 black Americans](. Those with the disease have a life expectancy that is 34 years shorter than the average. - KovaDx tried to help SCD patients by combining machine learning and 3D phase imaging. - KovaDx's closure is primarily due to a lack of funding, highlighting the difficulties in securing financial support for rare disease research. - This is part of a bigger trend. The health tech industry has seen a severe decline in funding. What Was KovaDx: KovaDx was a health tech startup founded by [Dr. Yaw Ansong-Ansongton](, who was inspired by his work as a doctor in Ghana, where he treated children with Sickle Cell Disease (SCD). SCD is a group of genetic red blood cell disorders that can lead to severe complications, such as strokes. It is a lifelong illness with no known cure and predominantly affects people of African ancestry. KovaDx developed a proof-of-concept Red Blood Cell Health Index, combining advanced imaging and machine learning. They hoped that this could help SCD patients by preventing severe episodes through routine monitoring. The Numbers: - 📅 Founded in 2019. - 🚀 Joined the [ABCT accelerator]( and received a $25K grant. - 💰 Raised $500K in different grants. Reasons For Failure: - Lack of Funding: KovaDx struggled to secure sufficient funding. While they managed to obtain some money through various grants, it was ultimately not enough. In a [post-mortem analysis](, Dr. Yaw wrote, "There was no money! I attribute this to the fact that we were targeting a rare disease that affects a typically low-resource community." - Conflicts among Co-Founders: In the post-mortem, Dr. Yaw also detailed numerous conflicts that arose between the three co-founders. Disagreements ranged from which market to target (Dr. Yaw wanted to focus on the African market, while the other co-founders chose to pivot to the US market) to disputes over equity percentages. These internal conflicts are common among co-founders and can be a significant, though often hidden, reason for startup failure. - Decline in HealthTech Funding: Securing funds for rare disease research is always challenging, and the recent decline in the HealthTech industry further hindered KovaDx. As shown in the graph below, venture capital funding in the industry peaked in 2021 but has experienced a sharp decline since then. Go Deeper: - Dr. Yaw’s [post-mortem analysis](. - Another company that is [working on curing SCD](. Win or Fail? Safe Superintelligence Inc (SSI) Last week, Ilya Sutskever, co-founder of OpenAI, launched [Safe Superintelligence Inc. (SSI)](. - The company aims to pioneer "Safe Superintelligence," emphasizing responsible AI development. - Sutskever [parted ways with OpenAI a month ago]( amid disagreements with its leadership on AI safety strategies. - He claimed the Superalignment team was not given enough resources to ensure AI safety correctly. - Following his departure, OpenAI no longer maintains a dedicated safety team. - Sutskever claims that SSI’s team, investors, and business model will allow them to focus on achieving Safe Superintelligence instead of having to follow short-term commercial pressures. Will SSI become the next OpenAI? [✅ He did it once, he can do it again!]( [❌ They are too far behind...]( Trend Claude 3.5 Sonnet Anthropic has released its latest AI model: [Claude 3.5 Sonnet](. Why it Matters: - Anthropic claims the model can go toe-to-toe against GPT4-o in reasoning, math, and coding. - It is now the most intelligent model in the Claude family and is also cheaper than its brother, Claude 3 Opus. - Like GPT4-o, Sonnet is a multimodal model. It has vision and can understand any image you upload. - This model positions Anthropic as the most important OpenAI competitor. The Claude Family The Claude family originally consisted of three models: - Claude 3 Haiku: The affordable, lightweight, but less intelligent model. - Claude 3 Sonnet: The mid-tier option. - Claude 3 Opus: The most intelligent yet most expensive model. Claude 3.5 Sonnet is an upgrade to the mid-tier model. It significantly boosts intelligence while maintaining the same price. This upgrade makes Claude 3.5 Sonnet the best overall model in the Anthropic lineup, offering a perfect blend of speed, intelligence, and affordability. Consequently, Claude 3 Opus now finds itself in an awkward position, being more expensive and less intelligent than Sonnet. The Benchmarks Anthropic benchmarks claim that Claude 3.5 Sonnet outperforms GPT, Gemini, and LLaMA in areas like reasoning, coding, and math. Additionally, Anthropic states that Claude 3.5 Sonnet is twice as fast as Claude 3 Opus. Its vision capabilities have also been significantly enhanced, bringing it much closer to GPT-4's multimodal capacities. However, Claude still lags behind GPT in some aspects: - It lacks voice interaction, so you cannot talk to the model as you can with GPT. - It does not have real-time vision like GPT-4. Its vision is limited to images. Artifacts Claude 3.5 Sonnet introduces a cool new feature called Artifacts. Essentially, Artifacts are separate windows that Claude creates when asked to generate content like text documents, website designs, or code. If you ask Claude to write code, a separate window that functions like an IDE will appear. Claude can even run the code, allowing you to preview it directly within the Artifact window. This will enable you to create apps or games inside the Claude platform. [tw profile: Des Traynor] Des Traynor @destraynor [tw] The latest @AnthropicAI's Claude + Artifacts is very cool. I've been discovering what's the most advanced games I can build in 2-3 prompts. So far a basic Doom, and decent enough Pacman are impressing me. What's the best you've seen? 3:37 PM • Jun 25, 2024 41 Likes 1 Retweet 4 Replies Help Me Improve Failory How Was Today's Newsletter? If this issue was a startup, how would you rate it? [🚀 Launches to the moon!]( [🤔 Room for a pivot]( [💀 Crashes and burns]( That's all of this edition. Cheers, Nico Update your email preferences or unsubscribe [here]( © 2024 Failory 1309 Coffeen Avenue Ste 1200, Sheridan, Wyoming 82801, United States of America [[beehiiv logo]Powered by beehiiv]( [Terms of Service](