Neuron: April 5, 2023 (Volume 111, Issue 7)

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[Webinar: Multi-omics data informing upon the cardiovascular system](%2F%2Fwww.workcast.com%2Fregister%3Fcpak=2214682748741296%26referrer=etoc/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/X3Kdg3j5m_VCCXZxpBsXOC9PA6YVyzLj9u3DAq1kigQ=295) March 30, 2023, 1:00 pm ET | available live & on demand. Featured articles --------------------------------------------------------------- [Attention in flux](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00165-4/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/oI9E8X-6AUuXiO45Y9lAvj-y9zczVQZWEt3ZFiGkpCE=295) Nobre et al. [Principles of large-scale neural interactions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00211-8/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/gQFkfyMMHBnzuKoGlSKqMGQkHuUiPWKg6nWWIUpy0EU=295) Vinck et al. [Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00213-1/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/meFvqoDKQL4L3HEctzX1ufsS4DGsO21IsB5BBXTM_9k=295) Hanganu-Opatz et al. [Solving the binding problem: Assemblies form when neurons enhance their firing rate&mdash:they don't need to oscillate or synchronize](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00212-X/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/Mn0WL6vHcV8Mw054Syr2d1O1aDcTchjXBbXO4zNGqvY=295) Pieter R. Roelfsema Online now --------------------------------------------------------------- [Identification of an essential spinoparabrachial pathway for mechanical itch](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00209-X/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/iSoy5V6MtEJhRRcy73vygiJOtEQpA010W911KUAy9ew=295) Ren et al. [Oxytocin promotes prefrontal population activity via the PVN-PFC pathway to regulate pain](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00210-6/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/-Xl0LHEmgGJEQqkUDDokzPxUmCi-LEHy5qXhw-a4-Hc=295) Liu et al. [Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00205-2/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/KtnxR5z_yPJMufyUT7P5P7k42LNtSu4g18rFQIvrLiE=295) Abdelfattah et al. [Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate?](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00206-4/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/Nw7lj9fancY01R1Pup5gmAKEo7WGgy0ncFSbaLvsLvo=295) Tosoni et al. Table of Contents Previews --------------------------------------------------------------- [Hush little baby, don’t you cry: How aversion to infant distress calls drives caregiving](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00199-X%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/dVLAE-HTJcbrWpf3sx4YoIcDIQuVec4Cm_UphLStYII=295) Ilaria Carta, Anita E. Autry Historically associated with aversion, the lateral habenula has a poorly characterized role in parenting. In this issue of Neuron, Lecca and colleagues show that these seemingly opposing roles converge in a subnucleus where aversion to pup cries may drive motivation for caregiving. [A new role for astrocytes in the story of cocaine abuse](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00200-3%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/nhI2YprkFAVxWwXPSVBnhFfscVJYu-Vo5coHW6WU7Zo=295) Giorgio Carmignoto, Marta Gomez-Gonzalo In this issue of Neuron, Yang et al.1 highlight a hitherto unknown action of cocaine in VTA circuitry. They found that chronic cocaine use increased tonic inhibition selectively onto GABA neurons through Swell1 channel-dependent GABA release from astrocytes, leading to disinhibition-mediated hyperactivity in DA neurons and addictive behavior. NeuroView --------------------------------------------------------------- [Brain rhythms have come of age](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00214-3%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/kcgC_OD4cjx5SE83AvOac6PmrvXCB5hKEqu0fVDPwqA=295) György Buzsáki, Mihály Vöröslakos Neuronal oscillations offer access to neuronal operations, bringing microscopic and macroscopic mechanisms, experimental methods, and explanations to a common platform. The field of brain rhythms has become the agora of discussions from temporal coordination of neuronal populations within and across brain regions to cognitive phenomena, including language and brain diseases. Q&A --------------------------------------------------------------- [Wolf Singer](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00215-5%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/i1-epqgERKXIpEPT96_e538KCPPflVJ4YhPewR8389s=295) Wolf Singer has long been interested in neural dynamics, synchrony, and temporal codes. On his 80th birthday, he talks with Neuron about his seminal contributions, the need to engage with the public on philosophical and ethical implications of scientific research, and further speculation about the future of neuroscience. [Jackie Gottlieb](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00216-7%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/5C4-FDXa4JvSvtzfzcro3y9E7-5e73iPKKkZTTAWq50=295) Jackie Gottlieb Reviews and perspectives --------------------------------------------------------------- [Over and above frequency: Gamma oscillations as units of neural circuit operations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00130-7%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/HhV2sIUelq8g0DrVcNcJ2sJ7G-GOwwLLY3BWCnsr6mM=295) Antonio Fernandez-Ruiz, Anton Sirota, Vítor Lopes-dos-Santos, David Dupret Open Access Gamma frequency oscillations are traditionally detected, discriminated, and classified based on their frequency. Fernandez-Ruiz and colleagues propose a unifying view of gamma oscillations as elemental units of neural operation defined and sorted based on their underlying circuit of generation. [Rhythmic attentional scanning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00119-8%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/rEUJP0fnzGrBKDpp9eUAI_nQruPifBt2K-pkRICZb3A=295) Pascal Fries Open Access This perspective by Fries presents the rhythmic attentional scanning (RAS) hypothesis. RAS proposes that the brain processes multiple concurrent items sequentially by scanning one item or chunk of items per theta cycle, with behaviorally relevant items being scanned more often. [Attention in flux](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00165-4%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/DVQWr_xD2Ohwwt7uTq9VWrue5DpF_dbepbbrJ5KTlKc=295) Anna C. Nobre, Freek van Ede Nobre and van Ede review attention in time, considering in turn the challenges to attention posed by the time dimension, the opportunities conferred by predictable temporal structures, and the insights gained by tracking attention through time. [Principles of large-scale neural interactions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00211-8%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/Wl7GAP7iibMbjR0HgLiWr8h1oMb9LzeJWqMomBU_1VU=295) Martin Vinck, Cem Uran, Georgios Spyropoulos, Irene Onorato, Ana Clara Broggini, Marius Schneider, Andres Canales-Johnson Vinck et al. discuss various mechanisms of flexible inter-areal communication. They argue for resonance and non-linear integration as viable alternative mechanisms to communication-through-coherence. Distinct roles for aperiodic transients and rhythmic equilibrium states in information coding and feedforward/feedback transmission are proposed. [Solving the binding problem: Assemblies form when neurons enhance their firing rate—they don’t need to oscillate or synchronize](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00212-X%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/mVnoCihBaKwNJv_13_sUmEtiNKGrfYIG21K_ECDm_sg=295) Pieter R. Roelfsema Roelfsema reviews the neuronal mechanisms for the binding of features into object representations in vision. Features are bound in perception when object-based attention neurons enhance the activity of neurons without a role for neuronal synchrony or oscillations. [Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00213-1%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/dsuTuIwfMggUKeJFXVTjboePOOftJ66bfFbY9gUsezM=295) Ileana L. Hanganu-Opatz, Thomas Klausberger, Torfi Sigurdsson, Andreas Nieder, Simon N. Jacob, Marlene Bartos, Jonas-Frederic Sauer, Daniel Durstewitz, Christian Leibold, Ilka Diester Hanganu-Opatz et al. review how temporal coordination and afferent and efferent connectivity dynamically support the building of neuronal ensembles during higher-order cognitive abilities, considering common mechanisms across species. [Spatial navigation and memory: A review of the similarities and differences relevant to brain models and age](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00169-1%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/y2hNG3QBe0S7ck_CUMMVcXn6qD0CY3sVZauaVWHduII=295) Arne D. Ekstrom, Paul F. Hill Neurobiological models often assume a correspondence between memory and spatial navigation based on the idea of the cognitive map. The authors review recent literature, highlighting important distinctions between memory and navigation and discussing novel models for their independent neural underpinnings. [Sleep—A brain-state serving systems memory consolidation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00201-5%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/HOB-Q3dVViY05mk5gxCXPVeshaM1DMF-C6MU0fp_uzg=295) Svenja Brodt, Marion Inostroza, Niels Niethard, Jan Born Brodt et al. review recent studies of synaptic and systems consolidation underlying long-term memory formation during sleep. While memory consolidation in both the sleep and wake states involves neuronal replay, only sleep consolidation critically relies on the hippocampal memory system. Reports --------------------------------------------------------------- [Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00202-7%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/TpkIIKrjTcLFc17C0MgJMrnjFJ-vR0iCWWwdHgWT46w=295) Donghoon Shin, Kayla Peelman, Anthony D. Lien, Joseph Del Rosario, Bilal Haider Neural oscillations pervade sensory systems; it remains unclear how oscillations coordinate spiking across brain areas. Shin et al. show synchronized narrowband gamma (NBG) oscillations across the thalamus, primary visual cortex, and higher visual areas. NBG improves sensory coding and aligns spikes of neurons preferring brights versus darks, a fundamental aspect of vision. [Virus exposure and neurodegenerative disease risk across national biobanks](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01147-3%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/_ppBdVxjuiMy-9K_MxMCRaubsmmpxBnttOPtHZxoxvs=295) Kristin S. Levine, Hampton L. Leonard, Cornelis Blauwendraat, Hirotaka Iwaki, Nicholas Johnson, Sara Bandres-Ciga, Luigi Ferrucci, Faraz Faghri, Andrew B. Singleton, Mike A. Nalls Open Access We identified 45 viral exposures significantly associated with increased risk of neurodegenerative disease and replicated 22 of these associations, including the association between the Epstein-Barr virus and multiple sclerosis. As vaccines are available for some of the associated viruses, vaccination may be a way to reduce risk of neurodegenerative disease. [A neural substrate for negative affect dictates female parental behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00027-2%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/1eDWSuPLzaW7wqGlpuuB_EmLySngCf2g5G_Ko3RhpUA=295) Salvatore Lecca, Mauro Congiu, Léa Royon, Leonardo Restivo, Benoit Girard, Noemie Mazaré, Camilla Bellone, Ludovic Telley, Manuel Mameli Newborn distress induces negative affect that can be limited through parental actions. However, whether neuronal circuit devoted to aversion encoding mediates parental behavior remains unknown. Lecca and colleagues identify neurons in the mouse habenula computing the aversive component of pup distress and subsequent parenting. Articles --------------------------------------------------------------- [Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01154-0%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/Eo25ycYPsZZcLzbQx9ODerJyTuCb9EaDjSsvthLCE00=295) Junhua Yang, Jianan Chen, Yongqing Liu, Kevin Hong Chen, Jay M. Baraban, Zhaozhu Qiu Yang et al. report that astrocytes in VTA release GABA through the volume-regulated anion channel Swell1 to regulate the activity of VTA GABA and dopamine neurons and modulate cocaine-induced locomotor and reward behaviors in mice. [Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01155-2%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/LDLaPQilJFGN5i5rNac5dDdHDAc6E_K1t3ipvQzg93o=295) Jianzhi Zeng, Xuelin Li, Renzimo Zhang, Mingyue Lv, Yipan Wang, Ke Tan, Xiju Xia, Jinxia Wan, Miao Jing, Xiuning Zhang, Yu Li, Yang Yang, Liang Wang, Jun Chu, Yan Li, Yulong Li The coincidence time window is the maximal temporal interval that allows two stimuli to be associated in Pavlovian learning. However, its neuronal mechanism remains unclear. Zeng et al. identify a serotonergic circuitry that regulates the coincidence time window for Drosophila olfactory learning, shedding light on the mystery left by Ivan Pavlov. [Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(23)00002-8%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/UrUNU6cuJWXp98ozKHkFRP8iAS3VO-hPyacRLRFKM_Q=295) Andreas Strube, Björn Horing, Michael Rose, Christian Büchel Open Access Strube et al. show that agency and positive treatment expectations additively enhance treatment success. EEG data suggest modulation by agency at expectation- and sensory-related processes. Computational modeling shows that this can be integrated as a prior shift in a Bayesian pain model. [Causal role of a neural system for separating and selecting multidimensional social cognitive information](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)01148-5%3Fdgcid=raven_jbs_etoc_email/1/010001875236ae58-1bb87150-3c3a-4247-8f2c-eb82fbe8b14c-000000/jTGMVOFbO-KIKQl040ebbQm5vQjObgaRajPhIeM0kkI=295) Ali Mahmoodi, Hamed Nili, Caroline Harbison, Sorcha Hamilton, Nadescha Trudel, Dan Bang, Matthew F.S. Rushworth Open Access Mahmoodi et al. identify distinct neural representations in dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI) supporting separation and selection of information for context-dependent, multidimensional social judgement. The distributed pattern of activity complements those linked to integration of information. Disruption of dmPFC and AI produce distinct changes in social judgement. 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