Neuron: March 2, 2022 (Volume 110, Issue 5)

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[Abstract submission deadline May 6, 2022 – submit your abstract here.](%2F%2Fwww.cell-symposia.com%2Fneuroimmunology-2022%2Fdefault.asp/2/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/SdrS1VcuA-EiLT3N1Uan1vXY5oCM3GGojz-5ZlZTr84=239) [The inclusion and diversity statement – one year on](%2F%2Fwww.cell.com%2Fnews-do%2Finclusion-and-diversity-statement-update-2022/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/HgXS7s_WUBQRszwseH4Uj5v7CSEQaC84_XhlG_NuG3g=239) As promised when we first introduced the initiative, we are using the first anniversary to take stock, report back, and consider next steps. [Read the update from Deborah Sweet, Vice President of Editorial.](%2F%2Fwww.cell.com%2Fnews-do%2Finclusion-and-diversity-statement-update-2022/2/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/dfwUJqSKixAVqcqrZseeN1rCy4H0efbAuSN18jRGZeQ=239) [Cell Symposia: Hallmarks of cancer](%2F%2Fwww.cell-symposia.com%2Fhallmarksofcancer-2022%2Fdefault.asp/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/J9M_QP0If4RZKvzVJJ34L8aMcNmaaVUDBNinyLoP-dQ=239) October 30–November 1, 2022 | San Diego, CA, USA. [Abstract submission deadline June 24, 2022 – submit your abstract here.](%2F%2Fwww.cell-symposia.com%2Fhallmarksofcancer-2022%2Fdefault.asp/2/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/yQlA1_JuOiSe4KqNqgnqCXQ3dBMRcaOyBVvYvFAYIXw=239) Featured articles --------------------------------------------------------------- [Confronting legacies of underrepresentation in clinical trials: The case for greater diversity in research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01016-3/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/spgRD6Wt4uQ3pNfXqJaH7_AL5RJYBWf3M8brcDhBHNI=239) Bernadette Boden-Albala [A functional subdivision within the somatosensory system and its implications for pain research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01032-1/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/uIlcs_z7AL3gRQsLo_F3LWsP_xwy3kpY6na4HpqgIDg=239) Qiufu Ma [Make war not love: The neural substrate underlying a state-dependent switch in female social behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00995-8/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/cvJ9CnN-q5705bRhtFuv8cuUHynGGKkOG2gEfl_S7Cs=239) Mengyu Liu, Dong-Wook Kim, Hongkui Zeng, David J. Anderson Online now --------------------------------------------------------------- [Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00108-8/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/WwNFqyvg7VZ3_cUH4cNSPuQPJ52aoDM8beIg_fV4etE=239) Krüttner et al [Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00105-2/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/-m4P7qPwlJ7jae1zqcG4VQbZ5e4NsHX9Cyo1piWs9kE=239) Harbauer et al [Coordinating cerebral cortical construction and connectivity: Unifying influence of radial progenitors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00104-0/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/rVzOhh_yWdkaY1vvoh8HDFL4F-fmsxlskKxgoz91D-g=239) Casingal et al [Beyond the neuron: Role of non-neuronal cells in stress disorders](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00102-7/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/jUbMiRSk7ke3M0LZm84VF_EJ6aAFCkMrkVYBFfAedXI=239) Cathomas et al Table of Contents Previews --------------------------------------------------------------- [Recycle before taking out the trash: ATG-9 exo-endocytosis links neuronal activity to autophagosome biogenesis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00107-6%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/WrEUvll0gDd2wd4ta-jSZFziP6cQlXjpkwY1XyZpDEY=239) Mónica C. Quiñones-Frías, Avital A. Rodal In this issue of Neuron, Yang et al. show that autophagy machinery is tightly coupled to neuronal activity via endocytic cycling of the transmembrane protein ATG-9 at presynaptic terminals. [From mating to mama bear: Distinct VMHvl cell types drive female reproductive state-dependent behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00145-3%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/4MtJEPxMYzJdtxeOqqsMpv9liwUE8U00Onjarj4nb9s=239) Shuyu Wang, Kimberly L.P. Long, Devanand S. Manoli In this issue of Neuron, Liu et al. (2022) molecularly identify subsets of estrogen receptor-1-positive neurons within the female ventrolateral subdivision of the ventromedial hypothalamus activated during sexual receptivity versus agonistic behaviors in distinct reproductive states and demonstrate that these subsets control state-dependent changes in social behaviors. [Taking a deep breath: How a brainstem pathway integrates pain and breathing](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00130-1%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/Zfjyd-RzlL1sEL3_OwCXfCcM0lsLiHz-kZdt4ln7irw=239) Justin Burdge, Z. Anissa Jhumka, Isabel M. Bravo, Ishmail Abdus-Saboor In this issue of Neuron, Liu et al. (2022) shed light on the neural circuits supporting pain- and anxiety-induced elevated breathing rhythms. They reveal PBL core-Oprm1 neurons projecting onto the CeA and shell-Oprm1 neurons projecting onto the preBötC as differential regulators of these behaviors. [Of pride and groom: The gains and limits of studying the neuroanatomy of rodent self-grooming in translational research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00131-3%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/03My-SQJ8SsUL3Cu8cSNJhi9cyFTgGlKdKompu9cwwA=239) Christiane Schreiweis, Eric Burguière In this issue of Neuron, Xie et al. characterize a cell-specific premotor circuit, generating rhythmic orofacial forelimb movements. The authors show that neurons of the caudal part of spinal trigeminal nucleus, expressing Cerebellin-2, are necessary and sufficient for triggering forelimb movements, which form a part of rodent self-grooming. [Replays of socially acquired information in the hippocampus](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00132-5%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/P1-PDdv2hB-9oID0R11cPIdnxQZNx50cgvSf5mp0ujk=239) Shigeyoshi Fujisawa, Ayako Ouchi Replays of place cell sequences in the hippocampus are thought to underlie memory consolidation for spatial learning. In this issue of Neuron, Mou et al. show that not only self-running but also social observation experiences promote awake remote replays for planning future journeys. NeuroView --------------------------------------------------------------- [Confronting legacies of underrepresentation in clinical trials: The case for greater diversity in research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01016-3%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/pK1zu_zaCJmgBkPmGALiZ7_3oQkp-ebhQj-Vn6qg-x8=239) Bernadette Boden-Albala Involvement of women and racial/ethnic minorities is critical to the scientific, economic, and ethical value of clinical trials. Despite legal precedents, diversity and inclusion in trials have been suboptimal. Bernadette Boden-Albala, MPH, DrPH, presents strategies to help investigators increase representation. Perspective --------------------------------------------------------------- [A functional subdivision within the somatosensory system and its implications for pain research](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01032-1%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/zk7Rxok4OAY9VWIph6EPHNIGEtgQeRTELgIrZUuQsh8=239) Qiufu Ma Ma proposes a functional subdivision of the somatosensory system into two branches that respond to external threats and internal body injuries, respectively. The conflation of these behavioral responses may contribute to the poor translation of therapies from preclinical pain studies. NeuroResource --------------------------------------------------------------- [A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00988-0%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/zObXejzhqAN4Cy3mbOh84zANR6Gg-yD2vSiaPDs46IQ=239) Zhaofa Wu, Kaikai He, Yue Chen, Hongyu Li, Sunlei Pan, Bohan Li, Tingting Liu, Fengxue Xi, Fei Deng, Huan Wang, Jiulin Du, Miao Jing, Yulong Li Wu et al. developed a sensitive GPCR activation-based ATP sensor, GRABATP1.0, for monitoring extracellular ATP dynamics under a variety of conditions. In zebrafish, GRABATP1.0 detected brain injury-induced in vivo propagation of ATP. In mouse cortex, GRABATP1.0 revealed ATP-releasing events at the resolution of a single astrocyte after LPS-induced inflammation. Report --------------------------------------------------------------- [Local feedback inhibition tightly controls rapid formation of hippocampal place fields](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00996-X%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/DB0bmYAyYUwIwZD667eY4L5w83JayX1KpKjwEp-MGQk=239) Sebi V. Rolotti, Mohsin S. Ahmed, Miklos Szoboszlay, Tristan Geiller, Adrian Negrean, Heike Blockus, Kevin C. Gonzalez, Fraser T. Sparks, Ana Sofia Solis Canales, Anna L. Tuttman, Darcy S. Peterka, Boris V. Zemelman, Franck Polleux, Attila Losonczy Rolotti, Ahmed, Szoboszlay et al. develop “all-optical” strategies to induce rapidly forming place fields in mouse CA1 and find that local feedback inhibition restricts recruitment of neurons into ensemble representations. Temporary relief of local inhibition permits the simultaneous induction of place fields in larger ensembles to enhance subsequent association learning. Articles --------------------------------------------------------------- [Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00992-2%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/WKWui0jUA6ayxplSAhV8NmN2x6Z5OeL0LBWzMQmS_Hc=239) Katrina Y. Choe, Richard A.I. Bethlehem, Martin Safrin, Hongmei Dong, Elena Salman, Ying Li, Valery Grinevich, Peyman Golshani, Laura A. DeNardo, Olga Peñagarikano, Neil G. Harris, Daniel H. Geschwind Using fMRI and c-Fos-iDISCO+, Choe et al. show that mice missing Cntnap2, an ASD-linked gene, exhibit altered functional brain connectivity. This is normalized by exogenous oxytocin, which also rescues social deficits. Critical to this process is endogenous oxytocin signaling within the NAc, implicating its potential role in ASD-associated social impairments. [Glutamate in primary afferents is required for itch transmission](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01015-1%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/388x7k-8obWJF8zfQx4xVFSJwzphvF57txXV0LVF2yc=239) Lian Cui, Jeff Guo, Suna L. Cranfill, Mayank Gautam, Janardhan Bhattarai, William Olson, Katherine Beattie, Rosemary C. Challis, Qinxue Wu, Xue Song, Tobias Raabe, Viviana Gradinaru, Minghong Ma, Qin Liu, Wenqin Luo Cui et al. demonstrate that glutamate is required for itch transmission in MRGPRA3+ primary afferents, which also use the neuropeptide NMB to enhance signaling. Because both glutamate and Nmb are broadly available in primary afferents, this suggests that distinct neurotransmitters are not necessary to confer itch modality specificity. [Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01076-X%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/9BTFbD-PKILReCPam7_5ryy6zRnW_Ma9-3LZkZqgh6I=239) Sisi Yang, Daehun Park, Laura Manning, Sarah E. Hill, Mian Cao, Zhao Xuan, Ian Gonzalez, Yongming Dong, Benjamin Clark, Lin Shao, Ifechukwu Okeke, Agustin Almoril-Porras, Jihong Bai, Pietro De Camilli, Daniel A. Colón-Ramos Autophagosome biogenesis occurs near synapses and increases with neuronal activity. The mechanisms that couple synaptic autophagy with synaptic activity remain unknown. Yang et al. provide evidence that ATG-9 is on vesicles that undergo activity-dependent exo-endocytosis at synapses, thus coupling autophagosome biogenesis at presynaptic sites with the activity-dependent synaptic vesicle cycle. [Make war not love: The neural substrate underlying a state-dependent switch in female social behavior](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00995-8%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/cZNvmpHfvMJvuH5SNIsynqHdGx3GkeGqObcJSDh6xTg=239) Mengyu Liu, Dong-Wook Kim, Hongkui Zeng, David J. Anderson Open Access Internal states can profoundly alter innate behavioral responses to releasing stimuli. Liu et al. identify distinct neural subpopulations within a single hypothalamic nucleus (VMHvl) that causally control female mating versus aggressive behaviors. Changes in the subpopulations’ relative cue sensitivity underlies a state-dependent switch in social behaviors. [Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00990-9%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/GOoFaPp8zSe-XnV_VKYKI5_KcQSaHisQOe6uKbW87VM=239) Shijia Liu, Mao Ye, Gerald M. Pao, Samuel M. Song, Jinho Jhang, Haibei Jiang, Jong-Hyun Kim, Sukjae J. Kang, Dong-Il Kim, Sung Han Breathing can be influenced by pain and anxiety, but the neural substrate underlying this connection is unknown. Liu et al. report that neurons in the lateral parabrachial nucleus expressing the μ-opioid receptor coordinate breathing with affective pain and negative emotions through divergent output circuits and local recurrent networks in mice. [A brain-to-spinal sensorimotor loop for repetitive self-grooming](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)00989-2%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/0FmnyK6f4kw31f5LZIk3BKwM799ZLQ6iIK9Wz50yZqU=239) Zhiyong Xie, Dapeng Li, Xinyu Cheng, Qing Pei, Huating Gu, Ting Tao, Meizhu Huang, Congping Shang, Dandan Geng, Miao Zhao, Aixue Liu, Chen Zhang, Fan Zhang, Yuanwu Ma, Peng Cao Xie et al. demonstrate that Cbln2-expressing neurons in the caudal part of the spinal trigeminal nucleus form a neural circuit to the cervical spinal cord to maintain repetitive orofacial self-grooming, suggesting a brain-to-spinal sensorimotor loop for repetitive behavior in mice. [Observational learning promotes hippocampal remote awake replay toward future reward locations](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(21)01013-8%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/GzM52TmgkRGRbuOlfbwKS1bdKw-2F5dZsSYZ4FiABjY=239) Xiang Mou, Abhishekh Pokhrel, Prakul Suresh, Daoyun Ji Mou et al. demonstrate that observing an animal running a maze reactivates the firing sequences of the observer’s hippocampal place cells remotely during awake ripples in a physically separated observation box. Such reactivation preferentially focuses on reward sites in the maze and predicts the observer’s future spatial decisions. Correction --------------------------------------------------------------- [Dynamic and reversible remapping of network representations in an unchanging environment](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(22)00133-7%3Fdgcid=raven_jbs_etoc_email/1/0100017f4ba4a586-39778e62-1f5c-47af-9c92-52d854d515d5-000000/LNHdmjmGo-S5OnskTX_0ApGo4l_iSkGLdaGy5vZ8pDA=239) Isabel I.C. Low, Alex H. Williams, Malcolm G. Campbell, Scott W. Linderman, Lisa M. 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