Neuron: June 19, 2024 (Volume 112, Issue 12)

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Featured articles --------------------------------------------------------------- [Neuroecological links of the exposome and One Health](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00277-0/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/DIXzTv6ictKD8fr3opKmFezc9PdMi8xMjmXKbdTo8Ko=358) Ibanez et al. [Neurobiological basis of stress resilience](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00327-1/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/BmzfgDmht3vCg8yqEDvwQb8SnnmLzwwOguLA0riKbPg=358) Nestler et al. [Monitoring norepinephrine release in vivo using next-generation GRABNE sensors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00155-7/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/3ePEpYLdS3pSj9FOsN-jZDbMlcu7tFr3VhKHv-HxykY=358) Feng et al. [Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00195-8/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/5U2kI0uABJSx8xfgTUcrsN1g6qnblQFnjcYSZH3kvGg=358) Umpierre et al. Online now --------------------------------------------------------------- [Opto-seq reveals input-specific immediate-early gene induction in ventral tegmental area cell types](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00373-8/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/XpvSLAxpAeBOODfSVktW3a3jThpoJvs7M96JwHbXCHk=358) Simon et al. [Microglia protect against age-associated brain pathologies](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00365-9/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/wQVWtjOh-xoOb0wOYezEvQZZ0PZHj91K5AkCAKo2tsA=358) Munro et al. [Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00370-2/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/JU3zIC9Q-RUNK7s8TkF2it1Bp2ES-r2rPjYzyTxTT6I=358) Chadarevian et al. [Neurodegeneration and demyelination in multiple sclerosis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00372-6/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/ReqhRFVNg6Q_uQPzaoYfdOdGOqnpY0Cai25RuOQK90o=358) Garton et al. Table of Contents Previews --------------------------------------------------------------- [Eyes on glutamate in angiogenesis and barrier formation](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00367-2%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/44rCORb8odxbs6VGMUbbXPvIaayeSBWjXH5oKBUVVmI=358) Yosuke Hashimoto, Matthew Campbell In this issue of Neuron, Biswas et al. demonstrate the roles of glutamatergic neuronal activity in the regulation of angiogenesis and retinal vascular endothelial barrier maturation using three different knockout mouse models. Their findings shed light on how aberrant glutamatergic activity can impact neural vascular function and barrier integrity. [Fuse mitochondria to win peer competition](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00331-3%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/ULb89zB1gvaeePRlpr213Dh3zxNVMGgwLuj2I32zowo=358) Lang Wang, Yan Gu In this issue of Neuron, Kochan et al. report that enhanced mitochondrial fusion is essential for the heightened synaptic plasticity in adult-born neurons during the critical period, thus supporting their competition with neurons of similar age for survival. [Tracking defensive states with prefrontal dynorphin-expressing neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00405-7%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/L3_IfTRmnUq42NEL5rhObeugh7yzo4pIm4QN1DwoAI8=358) Thomas Bienvenu, Cyril Dejean, Cyril Herry The dynamic suppression of threat-related behavior as a function of environmental constraint is critical for survival in mammals, yet the neurobiological underpinnings remain largely unknown. In this issue of Neuron, Wang et al. identified prefrontal dynorphin-expressing neurons as key elements for tracking threat-related behavioral states and regulating fear suppression. Obituary --------------------------------------------------------------- [Larry J. Young (1967–2024)](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00369-6%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/LNJX6YxrHBj4_nr_YWfXL8dWbEL4RjFtLIg7tygRbEI=358) Robert C. Liu, Anne Z. Murphy NeuroView --------------------------------------------------------------- [Neuroecological links of the exposome and One Health](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00277-0%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/lv6-lp_QDD2OO6tePk6jCGYcKK5jtAjITtCAkHguFpY=358) Agustin Ibanez, Lucia Melloni, Paweł Świeboda, William Hynes, Burcin Ikiz, Rym Ayadi, Massamba Thioye, Consuelo Walss-Bass, Bahar Güntekin, Jyoti Mishra, Mohamed Salama, Sarah Dunlop, Claudia Duran-Aniotz, Harris A. Eyre This NeuroView assesses the interplay among exposome, One Health, and brain capital in health and disease. Physical and social exposomes affect brain health, and green brain skills are required for environmental health strategies. Ibanez et al. address current gaps and strategies needed in research, policy, and technology, offering a road map for stakeholders. Review --------------------------------------------------------------- [Neurobiological basis of stress resilience](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00327-1%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/vghsyuaIWDwqEqxpeDyd2_UZqkNGDaN7sEw2XCexYCo=358) Eric J. Nestler, Scott J. Russo A majority of humans maintain normal function despite exposure to severe stress. Work in rodents reveals that such stress resilience is mediated largely by the induction of molecular, cellular, and circuit adaptations that actively drive resilience. Such discoveries are guiding the development of novel treatments for human stress disorders. NeuroResource --------------------------------------------------------------- [Monitoring norepinephrine release in vivo using next-generation GRABNE sensors](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00155-7%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/nAEb0upb0AccEDLjH3GzhFMhyB3OcMpoiDoSRq8zJWw=358) Jiesi Feng, Hui Dong, Julieta E. Lischinsky, Jingheng Zhou, Fei Deng, Chaowei Zhuang, Xiaolei Miao, Huan Wang, Guochuan Li, Ruyi Cai, Hao Xie, Guohong Cui, Dayu Lin, Yulong Li Feng et al. optimized a pair of GRABNE sensors with enhanced norepinephrine (NE) sensitivity both in vitro and in vivo. They also developed a Cre-dependent knockin transgenic mouse line for cell-type-specific dual-color imaging of NE and calcium, unveiling distinct neuromodulation dynamics across physiological states. Articles --------------------------------------------------------------- [MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00245-9%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/q8GNclNJPOlhsxoFwwa5vCkv1ZCxNbrFkXF-vDpAHuU=358) Yi Liu, Anthony Flamier, George W. Bell, Annette Jun Diao, Troy W. Whitfield, Hao-Che Wang, Yizhe Wu, Fabian Schulte, Max Friesen, Ruisi Guo, Maisam Mitalipova, X. Shawn Liu, Seychelle M. Vos, Richard A. Young, Rudolf Jaenisch Liu et al. utilized epigenomic, proteomic, and transcriptomic profiling to identify a conserved MECP2-RNA Pol II module critical for the regulation of neuronal gene expression, in particular to autism risk genes. Alteration to this module caused by MECP2 patient mutations leads to transcriptional dysregulation associated with Rett syndrome (RTT). [Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00195-8%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/OgPmLajnpm08Kw181QO2ylGk-yBLopfFlpepkLUueNk=358) Anthony D. Umpierre, Bohan Li, Katayoun Ayasoufi, Whitney L. Simon, Shunyi Zhao, Manling Xie, Grace Thyen, Benjamin Hur, Jiaying Zheng, Yue Liang, Dale B. Bosco, Mark A. Maynes, Zhaofa Wu, Xinzhu Yu, Jaeyun Sung, Aaron J. Johnson, Yulong Li, Long-Jun Wu Umpierre, Li, et al. demonstrate that post-seizure UDP release can activate microglial calcium activity through the P2Y6 receptor. UDP-P2Y6 signaling engages multiple aspects of immune function during early epilepsy development, including engulfment of neuronal somata and pro-inflammatory cytokine production. P2Y6 deficiency attenuates pyramidal cell loss and cognitive impairment. [Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00165-X%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/lrsGkKPHBh_g2eo6Tb2rCmmUOcrue9bejzOf3Q2Ppto=358) Saptarshi Biswas, Sanjid Shahriar, Galina Bachay, Panos Arvanitis, Danny Jamoul, William J. Brunken, Dritan Agalliu Biswas et al. demonstrate that glutamate released by retinal neurons induces Norrin expression in Müller glia and interneurons, promoting deep plexus angiogenesis and blood-retinal barrier maturation. These findings further our understanding of retinal vascular development and may help identify therapeutic targets for retinal pathologies where neuronal dysfunction precedes vascular pathologies. [Enhanced mitochondrial fusion during a critical period of synaptic plasticity in adult-born neurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00167-3%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/bhRxz-zyB3aE938FrX4bUcYX7gogcRQ15sq7R69Ah68=358) Sandra M.V. Kochan, Meret Cepero Malo, Milica Jevtic, Hannah M. Jahn-Kelleter, Gulzar A. Wani, Kristiano Ndoci, Laura Pérez-Revuelta, Felix Gaedke, Iris Schäffner, Dieter Chichung Lie, Astrid Schauss, Matteo Bergami Open Access Circuit integration of adult-born neurons maintains high levels of plasticity in the adult brain. Kochan et al. show that a burst in fusion promotes stable and elongated mitochondrial morphologies along the dendrites of new neurons, fueling experience-dependent synaptic plasticity and competition dynamics within the hippocampal network. [Somatostatin interneurons control the timing of developmental desynchronization in cortical networks](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00168-5%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/yYutSc79wBCypcFMx-DkEH1rrQIqIsmeSEEkJ3CZd-o=358) Laura Mòdol, Monika Moissidis, Martijn Selten, Fazal Oozeer, Oscar Marín Open Access Mòdol and colleagues show that somatostatin interneurons modulate critical transitions in network dynamics during early postnatal development, leading to the maturation of cortical circuits. This process is mediated through the gradual integration of sensory inputs into local dynamics and involves the progressive maturation of parvalbumin interneurons. [Nr4a1 regulates cell-specific transcriptional programs in inhibitory GABAergic interneurons](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00196-X%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/7bIahvTKz8iGsXKgOtn0N2CYwuCScWYlFbZ8di3ZSqI=358) Min Huang, Simon Pieraut, Jasmine Cao, Filip de Souza Polli, Vincenzo Roncace, Gloria Shen, Carlos Ramos-Medina, HeeYang Lee, Anton Maximov Huang et al. report that the immediate-early gene Nr4a1 regulates the connectivity and physiological properties of inhibitory GABAergic interneurons in the mouse brain. Nr4a1 appears to exert these effects by controlling the cell-specific expression of multiple gene families, including those essential for synapse formation and maintenance. [Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00197-1%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/HBdf2Q7orevM1_bqVyPO_kcWCmIUBJtXEQHilQZRW1E=358) Dámaris K. Rangel Guerrero, Kira Balueva, Uladzislau Barayeu, Peter Baracskay, Igor Gridchyn, Michele Nardin, Chiara Nina Roth, Peer Wulff, Jozsef Csicsvari Open Access Rangel Guerrero et al. silenced the activity of CA1 Cholecystokinin-expressing interneurons. Optogenetic silencing disrupted the theta oscillation-related temporal coding of place cells during exploration while sleep replay was enhanced. Chemogenetic silencing enhanced the recall of contextual fear memories the next day and enabled the differentiation of similar environments. [Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00193-4%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/4ie3iYeapH1Yuw4SWfDRbBhw03Llz4Nc8LuE6p3IjP4=358) Huikun Wang, Rodolfo J. Flores, Hector E. Yarur, Aaron Limoges, Hector Bravo-Rivera, Sanne M. Casello, Niharika Loomba, Juan Enriquez-Traba, Miguel Arenivar, Queenie Wang, Robert Ganley, Charu Ramakrishnan, Lief E. Fenno, Yoon Kim, Karl Deisseroth, Grace Or, Chunyang Dong, Mark A. Hoon, Lin Tian, Hugo A. Tejeda Wang et al. demonstrate that ventromedial prefrontal cortex (vmPFC) prodynorphin cells are broadly activated by threats and release dynorphin to limit passive defensive behaviors. Furthermore, they demonstrate that dynorphin neuropeptidergic transmission suppresses passive defensive behaviors by facilitating a switch in vmPFC networks to a persistent fear-related state driven by acute threats. Correction --------------------------------------------------------------- [Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist](%2F%2Fwww.cell.com%2Fneuron%2Ffulltext%2FS0896-6273(24)00368-4%3Fdgcid=raven_jbs_etoc_email/1/010001903137886d-50a2858a-80f2-4b0e-a972-b5d7af3b4e0a-000000/e0xU7kC21zQTknsGomxcgD1sdpCG7Rcw8fZaRmd__Lk=358) Alexandra Litvinchuk, Jung H. Suh, Jing L. Guo, Karin Lin, Sonnet S. Davis, Nga Bien-Ly, Eric Tycksen, G. Travis Tabor, Javier Remolina Serrano, Melissa Manis, Xin Bao, Choonghee Lee, Megan Bosch, Enmanuel J. Perez, Carla M. Yuede, Anil G. Cashikar, Jason D. Ulrich, Gilbert Di Paolo, David M. 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