AwesomeStocks Donât want emails from us anymore? Click [here]( to unsubscribe. Hello! New Alert: Tiziana Life Sciences Ltd (NASDAQ: TLSA) TLSA is our new NASDAQ alert and a previous winner. Following our last alert in April, TLSA was trading at just 0.59. This week, TLSA reached a high of 1.05, upside of +77% from our last alert. Since our last update, TLSA announced multiple developments that could be additional growth catalysts. As a reminder, TLSA is a NASDAQ listed âclinical-stage biopharmaceutical company developing breakthrough therapiesâ. TLSA uses âtransformational drug delivery technologies to enable alternative routes of immunotherapyâ. The companyâs âinnovative nasal approach has the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous (IV) deliveryâ. TLSAâs âlead candidate, intranasal foralumab, which is the only fully human anti-CD3 mAb, has demonstrated a favorable safety profile and clinical response in patients in studies to dateâ. Furthermore, the companyâs âtechnology for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline applicationsâ. As the company further explains: âActivated T cells play an important role in the inflammatory process.â âForalumab, the only fully human anti-CD3 monoclonal antibody (mAb), binds to the T cell receptor and dampens inflammation by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets.â In addition: âThis effect has been demonstrated in patients with COVID and with multiple sclerosis, as well as in healthy normal subjects.â Importantly: âThe non-active SPMS intranasal foralumab Phase 2 trial dosed its first patient in December of 2023.â âImmunomodulation by nasal anti-CD3 mAb represents a novel avenue for treatment of neuroinflammatory and neurodegenerative human diseases.â Sadly, âMultiple sclerosis (MS) is one of the most widespread disabling neurological conditions of young adults around the worldâ. âRecent findings from the National MS Society estimate that nearly 1 million people in the United States are living with MSâ. Following our last alert, TLSA has announced multiple accomplishments that could be additional growth catalysts. In April, the company announced: âTiziana Life Sciences Announces Additional Clinical Improvements Among Multiple Sclerosis Patients in its Expanded Access Programâ Here are the highlights from this press release: - â70% of Patients in the Expanded Access Program (EAP) Have Seen Measurable Clinical Improvement in Their Fatigue After Six Months of Follow-upâ
- âAll Patients Have Either Stabilized or Improved on Nasal Foralumab Treatment and No Patients Declined in Key Clinical Measuresâ Here are some of the comments from this press release: âGabriele Cerrone, Chairman, acting CEO and founder of Tiziana Life Sciences, commented âFatigue is a pervasive and challenging symptom for individuals living with MS, impacting their daily lives in profound ways. The clinically meaningful improvement in fatigue levels seen in seven out of ten patients, as well as the stabilization or improvements in other key clinical outcome measures that were seen in all patients, underscores the potential of Tiziana's investigational therapy to address this critical unmet need.ââ In addition, the company also announced: âTiziana Life Sciences Announces FDA Allowance for Additional Twenty Patients to be Enrolled in the Intranasal Foralumab Multiple Sclerosis Expanded Access Programâ Here are some of the comments from this press release: âGabriele Cerrone, Chairman, acting CEO and founder of Tiziana Life Sciences commented, âTiziana is glad to provide patients with na-SPMS who do not qualify to be enrolled on our Phase 2 trial (NCT06292923) the possibility to receive open-label treatment with our intranasal fully human anti-CD3 monoclonal-antibody, foralumab. As there are no FDA approved treatments for na-SPMS, an EA program gives these patients access to this novel drug.ââ Plus, the company also announced: - âTiziana Life Sciences Reports Positive 3-Month Neuroimaging Scores in Multiple Sclerosis Patients Receiving Intranasal Foralumabâ In May, the company announced: âTiziana Life Sciences Files for Orphan Drug Designation for Intranasal Foralumabâ Here are the comments from this press release: ââOrphan Drug Designation is granted by the FDA to drugs or biologics intended to treat a rare disease or condition, defined as one that affects fewer than 200,000 people in the U.S.,â commented Gabriele Cerrone, Chairman, acting CEO, and founder of Tiziana Life Sciences. âOrphan Drug Designation allows for up to seven years of marketing exclusivity if the product is ultimately approved for its designated indication, as well as providing the opportunity for other financial incentives to assist with development. It therefore carries significant value to our company and shareholders,â he concluded.â The company also announced: âTiziana Life Sciences Scientific Board Chairman to Receive Prestigious Award for Multiple Sclerosis Researchâ As the company further explained: âThe âGiants of MSâ award is presented annually by the Consortium of Multiple Sclerosis Centers (CMSC) and is the largest North American multi-disciplinary membership organization dedicated to defining and advancing the standard of care of MS patients. This award acknowledges individuals who have demonstrated extraordinary leadership and innovation in the field of MS research. Dr. Weiner's receipt of this esteemed accolade underscores his profound impact on advancing understanding of the underlying mechanisms of MS and driving therapeutic innovation in this field.â In addition, this week, on Monday, the company announced: - âTiziana Life Sciences Submits Grant Application to ALS Association to Fund Clinical Trial of Intranasal Foralumabâ TLSA could be positioned for continued growth. Make sure to do your own due diligence. Sources: [Healthline]( [PR1]( [PR2]( [PR3]( [PR4]( [PR5]( [PR6]( [PR7]( [Website]( [Chart]( Happy Trading! AwesomeStocks Note: We encourage all traders and investors to develop personal trading rules that you can follow and that work for you. Always protect your downside and note that we alert extremely volatile short-term opportunities. Before investing in securities, you should always consult with your financial, tax and legal advisor and never invest money you cannot afford to lose. 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