Cure for chronic pain – without side effects

When chronic pain takes over your life, you’d do almost anything to feel better… [Click here](198850/ct0_0/1/ms?sid=TV2%3AY4N2kDMOT) to view this message in your browser | [Click here](198850/l-002e/zout?sid=TV2%3AY4N2kDMOT) to stop receiving our messages [] [] Al Sears, MD 11905 Southern Blvd. Royal Palm Beach, FL 33411 [] October 9, 2024 [] Reader, When chronic pain takes over your life, you’d do almost anything to feel better… But I tell my patients that treating daily pain with a Big Pharma pill should be your last resort – not the first. Even over-the-counter pain pills can be almost as dangerous as prescription painkillers. Like acetaminophen. Don’t get me wrong. It’s fine to take Tylenol when you have an occasional headache or fever. The problem is most doctors — as well as all those TV commercials — suggest you take it every few hours to keep pain at bay. And by now, you probably know that every dose of acetaminophen puts a tiny, toxic burden on your liver. And this liver damage can happen even when you take Tylenol for just a few weeks at the recommended dosage. Acetaminophen overdose is one of the most common poisonings worldwide. [sears] The roots of this leafy plant contain curcumin, a powerful anti-inflammatory. It accounts for more than 56,000 emergency room visits, 26,000 hospitalizations, and 500 deaths in the U.S. due to acute liver failure each year.1 And liver damage can turn into liver failure in just one day. The sad thing is, the FDA knew about acetaminophen’s liver danger since 1977. But it took almost 40 years before the agency demanded a warning be added to the drug label. I tell my patients that instead of treating pain symptoms – and risking a dangerous overdose or liver damage – they need to get to the root of what’s causing their distress… Inflammation. And runaway inflammation is the underlying cause of all pain. Acetaminophen is not an anti-inflammatory drug. It won’t reduce swelling or inflammation. I’ve spent my life searching for better answers for my patients. I use nature’s pharmacy to help my patients heal. For long-lasting, effective, and safe relief from chronic pain, I recommend you target your body’s inflammatory response right at the source — the molecule nuclear factor-kappa B (NF-kB). This is your body’s inflammation command center. You see, NF-kB is the “switch” that activates over 400 of our body's pro-inflammatory genes. Including the enzymes COX-2, iNOS, and LOX. As a result, it provides your body with the blueprint for regulating its inflammatory response. Big Pharma considers it the “Holy Grail” for age-related inflammation. But they’ve failed to reliably and safely target it using drugs.2 But that’s okay. Because nature already designed two powerful NF-kB deactivators: curcumin and ginger. Curcumin’s effects on NF-kB and reducing inflammatory pain are well-known.3,4,5 But what’s less known is that ginger does the exact same thing.6 When you combine them, they’re a powerful duo against the leading cause of age-related inflammation. That’s also why studies point to ginger as such a powerful joint remedy. One double-blind study treated 120 joint patients with either a placebo or gingerol. In just 12 weeks, the ginger group saw remarkably healthy inflammation markers. The researchers conclude it’s because the gingerol extract deactivated the NF-kB gene.7 In fact, researchers at the University of Miami are saying that ginger could be a first-line joint treatment.8 In a double-blind study, they compared gingerol extract to a placebo in 261 knee joint patients. They found the ginger supported healthy joint comfort by 40% over the placebo…in just six weeks. Knock Out Pain With This 1-2 Punch It’s almost impossible to get the therapeutic doses you need from food. I recommend supplementing. Here’s what I tell my patients: - Get the right kind of curcumin. Curcumin is the active ingredient in turmeric. Most drugstore brands contain just a measly 450 mg. But you need at least 2,000 mg. But that’s not the only issue with drugstore supplements… It turns out curcumin has limited bioavailability. That means most of it gets metabolized before it can be absorbed due to the digestive enzymes in the stomach, intestines, and liver. Look for a supplement that also contains piperine. This black pepper compound has been shown to make curcumin more bioavailable. Piperine is a potent inhibitor of drug metabolism. It works by protecting curcumin from the digestive enzymes that are working to remove it from your blood. To further increase bioavailability, take it with a healthy fat. - Ease inflammation pain with ginger. Look for a supplement that is standardized to contain 5% gingerols. Ginger powders and extracts have been used in clinical trials at a variety of doses, often between 200 mg and 2 grams a day. Higher doses can cause stomach distress. If you choose to consume raw ginger, keep in mind that 1 teaspoon of raw ginger root is about 2 grams. I enjoy adding fresh ginger to my turmeric tea. This time of year, I make it as an iced tea. This is the recipe I use… - 2 cups water - 1-inch fresh turmeric root, peeled and thinly sliced - ½ tsp freshly chopped ginger - 1 Tbsp organic honey - Lemon wedges Boil water in a small pan, then add the first four ingredients. Lower heat to medium-low and let simmer for 10 minutes. Strain into a large glass, and add ice, honey, and lemon. To Your Good Health, Al Sears, MD, CNS --------------------------------------------------------------- References: - Agrawa S, Khazaeni B. “Acetaminophen toxicity.” NIH: National Center for Biotechnology Information. StatPearls Publishing. 2024 Jan. - Lawrence T. “The nuclear factor NF-KappaB pathway in inflammation.” Cold Spring Harb Perspect Biol. 2009 Dec;1(6). - Jobin C, et al. “Curcumin blocks cytokine-mediated NF-ΚB activation and proinflammatory gene expression by inhibiting inhibitory factor I-ΚB kinase activity.” J Immunol. 1999.163;(6):3474-3483. - Chandran B, Goel A. “A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis.” Phytother Res. 2012 Mar 9. - Shep D, et al. “Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.” 2019 Apr 11;20(1):214. - Lee HY, et al. “1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes.” Br J Pharmacol. 2012 Sep;167(1):128-40 - Naderi Z, et al. “Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial.” J Tradit Complement Med. 2015 Jan 28;6(3):199-203. - Altman RD, et al. “Effects of a ginger extract on knee pain in patients with osteoarthritis.” Arthritis Rheum. 2001 Nov;44(11):2531–8. alsearsmd@send.alsearsmd.com [Preferences | Unsubscribe](198850/l-002e/zout?sid=TV2%3AY4N2kDMOT) 11905 Southern Blvd., Royal Palm Beach, Florida 33411, United States